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Cynomolgus monkey IL6 Gene cDNA Clone (full-length ORF Clone)

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IL6cDNA Clone Product Information
Gene Bank Ref.ID:unsubmitted
cDNA Size:639
cDNA Description:ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) interleukin 6 (interferon, beta 2) DNA.
Gene Synonym:IL6
Species:Cynomolgus
Vector:pGEM-T Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with NM_001042756.1 [ Macaca mulatta (Rhesus monkey) ]: 112 A/G and 614 A/G resulting in the amino acid Asn substitution by Asp, Asn substitution by Ser. Please check the sequence information before order.
Shipping Carrier:Whatman FTA elute card (Cat: WB120410) contains 5-10 μg of plasmid.
Storage:The Whatman FTA elute card can be stored at room temperature for three months under dry condition.
pGEM-T vector information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
IL-6 Family & Receptor Related Products
Product nameProduct name
Human IL6ST / gp130 / CD130 Protein (His & Fc Tag)Human IL6ST / gp130 / CD130 ProteinHuman NNT1 / CLCF1 / CLC Protein (Fc Tag)Canine IL11RA / IL-11RA / IL11Rα ProteinRat CNTF / Ciliary Neurotrophic Factor ProteinRat CNTFR / CNTFR-alpha Protein (His Tag)Rat GM-CSF / CSF2 Protein (Fc Tag)Rat GM-CSF / CSF2 Protein (His Tag)Rat gp130 / IL6ST / CD130 Protein (His & Fc Tag)Rat gp130 / IL6ST / CD130 Protein (His Tag)Human CNTFR / CNTFR-alpha Protein (His Tag)Human Leptin ProteinRat IL6 / Interleukin-6 ProteinMouse IL11RA / IL11Rα Protein (His Tag)Mouse Oncostatin M / OSM Protein (His Tag)Mouse Oncostatin M / OSM ProteinRat LIFR Protein (His Tag)Human LIFR / CD118 Protein (His Tag)Human G-CSFR / CD114 / CSF3R Protein (Fc Tag)Human G-CSFR / CD114 Protein (His Tag)Human G-CSFR / CD114 / CSF3R ProteinHuman GM-CSF / CSF2 Protein (Fc Tag)Human IL11RA / IL11Rα Protein (His Tag)Mouse IL6ST / CD130 Protein (His & Fc Tag)Mouse IL6ST / gp130 / CD130 Protein (His & Fc Tag)Mouse IL6ST / gp130 / CD130 Protein (His Tag)Mouse IL6 / Interleukin-6 ProteinMouse CNTF / Ciliary Neurotrophic Factor Protein (His Tag)Canine IL11RA / IL-11RA / IL11Rα Protein (His Tag)Human IL-31 / IL31 Protein (His Tag)Human CSF2RA / GM-CSFR / CD116 Protein (His Tag)Human CSF2RA / GM-CSFR / CD116 Protein (Fc Tag)Mouse LIF Protein (Fc Tag)Mouse LIF Protein (His Tag)Mouse GM-CSF / CSF2 ProteinHuman G-CSF / CSF3 Protein (isoform b)Human Leptin Receptor / LEPR / CD295 Protein (His & Fc Tag)Human Leptin Receptor / LEPR / CD295 Protein (His Tag)Human Oncostatin M / OSM ProteinCynomolgus / Rhesus IL6 / Interleukin-6 ProteinHuman GM-CSF / CSF2 ProteinHuman GM-CSF / CSF2 ProteinHuman LIF ProteinCynomolgus IL6ST / gp130 Protein (Fc Tag)Cynomolgus IL6ST / gp130 Protein (His Tag)Mouse IL6RA / CD126 Protein (His Tag)Human G-CSF / CSF3 Protein (isoform b)Mouse LIF ProteinHuman CNTF Protein (His Tag)Mouse GM-CSF / CSF2 Protein (Fc Tag)Mouse GM-CSF / CSF2 Protein (His Tag)Human G-CSF / CSF3 Protein (Fc Tag)Human GM-CSF / CSF2 Protein (His Tag)Human IL11 / Interleukin 11 / IL-11 ProteinHuman OSMR / IL31RB Protein (His Tag)Human IL6 / Interleukin-6 ProteinHuman IL6R / CD126 Protein (His Tag)Mouse LIFR / CD118 Protein (His Tag)Human LIF Protein (Fc Tag)Human LIF Protein (His Tag)Human Oncostatin M / OSM Protein (His Tag)Mouse OSMR / IL-31RB Protein (His Tag)
Background

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

References
  • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
  • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
  • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"