- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
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Interleukin 6 Protein Datasheet
IL6 / Interleukin-6 Protein Price Inquiry ( Available Sizes )
IL6 / Interleukin-6 Protein Product Information
|Synonym :||IL6, Il-6|
A DNA sequence encoding the mouse IL6 (P08505) (Phe25-Thr211) was expressed and purified.
IL6 / Interleukin-6 Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
IL6 / Interleukin-6 protein
|1. Measured by its ability to bind biotinylated rat IL6ST-mFch (Cat:80030-R06H) in a functional ELISA.
2. Measured by its ability to bind biotinylated mouse IL6ST-Fc2h (Cat:50135-M03C) in a functional ELISA.
3. Measured by its ability to bind biotinylated mouse IL6ST-His (Cat:50135-M08H) in a functional ELISA.
4. Measured by its ability to bind biotinylated human IL6RB-Fch (Cat:10974-H03H) in a functional ELISA.
5. Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 0.4-2 ng/ml.
|Endotoxin:||Please contact us for more information.|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met|
The recombinant mouse IL6 consists of 188 amino acids and predicts a molecular mass of 21.9 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
IL6 / Interleukin-6 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
IL6 / Interleukin-6 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|IL-6||Human||IL-6 Protein, Recombinant||10395-HNAE|
|IL-6||Mouse||IL6 / Interleukin-6 Protein, Recombinant, with Native||50136-MNAE|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human IL-6||ELISA||Mouse Monoclonal Antibody||10395-MM02|
|Human IL-6||ELISA||Rabbit Polyclonal Antibody||10395-RP01|
|Human IL-6||WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||10395-RP03|
|Human IL-6||WB, ELISA||IL-6 Antibody||10395-R057|
IL6 / Interleukin-6 Protein Description
Interleukin 6 (IL-6, IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL-6/IL6 is a cytokine with a wide variety of biological functions and belongs to the IL-6 superfamily. IL-6/IL6 is a potent inducer of the acute phase response and plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. IL-6/IL6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1Ra and IL-10. IL-6/IL6 is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6/IL6 is also essential for hybridoma growth and is found in many supplemental cloning media such as briclone. Inhibitors of IL-6 are used to treat postmenopausal osteoporosis. IL-6/IL6 is thought to be a reason why obese individuals have higher endogeneous levels of CRP. Intranasally administered IL-6 was shown to improve sleep-associated consolidation of emotional memories.
- Kishimoto T. et al., 1995, Blood. 86: 1243-54.
- Heinrich PC. et al., 1998, Biochem J. 334: 297-314.
- Heinrich PC. et al., 2003, Biochem J. 374: 1-20.
- Chung HW. et al., 2003, J Hum Genet. 48:243-8.
- Schwantner A. et al., 2004, J Biol Chem. 279 (1): 571-6.
- Dubi ski A. et al., 2007, Pol Merkur Lekarski. 22 (130): 291-4.
|Interleukin / Interleukins|