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Mouse IL6 / Interleukin-6 Protein
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Mouse IL6 / Interleukin-6 Protein (Cytokine) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
50136-MNAE  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Interleukin 6 Protein Datasheet

 

IL6 / Interleukin-6 Protein Price Inquiry ( Available Sizes )

IL6 / Interleukin-6 Protein Product Information

Synonym : IL6, Il-6
Protein Construction:

A DNA sequence encoding the mouse IL6 (P08505) (Phe25-Thr211) was expressed and purified.

Source: Mouse
Expression Host: E.coli

IL6 / Interleukin-6 Protein QC Testing

Purity: > 95 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

IL6 / Interleukin-6 protein

Bio-activity:

1. Measured by its ability to bind biotinylated rat IL6ST-mFch (Cat:80030-R06H) in a functional ELISA.
2. Measured by its ability to bind biotinylated mouse IL6ST-Fc2h (Cat:50135-M03C) in a functional ELISA.
3. Measured by its ability to bind biotinylated mouse IL6ST-His (Cat:50135-M08H) in a functional ELISA.
4. Measured by its ability to bind biotinylated human IL6RB-Fch (Cat:10974-H03H) in a functional ELISA.
5. Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 0.4-2 ng/ml.
Endotoxin: Please contact us for more information.
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Met
Molecular Mass:

The recombinant mouse IL6 consists of  188 amino acids and predicts a molecular mass of 21.9 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH 7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

IL6 / Interleukin-6 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL6 / Interleukin-6 Protein Related Products & Topics

Related Areas:

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-6

Cancer>>Cancer Biomarkers>>IL-6

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-6 Family & Receptor>>IL-6

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IL-6 Human IL-6 Protein, Recombinant 10395-HNAE
IL-6 Mouse IL6 / Interleukin-6 Protein, Recombinant, with Native 50136-MNAE

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human IL-6 ELISA Mouse Monoclonal Antibody 10395-MM02
Human IL-6 ELISA Rabbit Polyclonal Antibody 10395-RP01
Human IL-6 WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10395-RP03
Human IL-6 WB, ELISA IL-6 Antibody 10395-R057

IL6 / Interleukin-6 Protein Description

Interleukin 6 (IL-6, IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL-6/IL6 is a cytokine with a wide variety of biological functions and belongs to the IL-6 superfamily. IL-6/IL6 is a potent inducer of the acute phase response and plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. IL-6/IL6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1Ra and IL-10. IL-6/IL6 is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6/IL6 is also essential for hybridoma growth and is found in many supplemental cloning media such as briclone. Inhibitors of IL-6 are used to treat postmenopausal osteoporosis. IL-6/IL6 is thought to be a reason why obese individuals have higher endogeneous levels of CRP. Intranasally administered IL-6 was shown to improve sleep-associated consolidation of emotional memories.

References

  1. Kishimoto T. et al., 1995, Blood. 86: 1243-54.
  2. Heinrich PC. et al., 1998, Biochem  J. 334: 297-314.
  3. Heinrich PC. et al., 2003, Biochem  J. 374: 1-20.
  4. Chung HW. et al., 2003, J Hum Genet. 48:243-8.
  5. Schwantner A. et al., 2004, J Biol Chem. 279 (1): 571-6.
  6. Dubi ski A. et al., 2007, Pol Merkur Lekarski. 22 (130): 291-4.
 

All IL-6 Proteins

Product name Product name
CD114 / G-CSFR / GCSFR Protein G-CSFR / CD114 Protein (His Tag)
CD114 / G-CSFR / GCSFR Protein Mouse OSMR / IL-31RB Protein (His Tag)
IL6 / Interleukin-6 Protein (Native) Oncostatin M / OSM Protein (His Tag)
IL6R / CD126 Protein (His Tag) Mouse LIF Protein
Leptin Receptor / LEPR / CD295 Protein Mouse LIF Protein (His Tag)
Leptin Protein (Native) Mouse IL6ST / gp130 / CD130 Protein
LIFR / CD118 Protein (His Tag) Mouse Oncostatin M / OSM Protein (His Tag)
IL6ST / gp130 / CD130 Protein Mouse IL6 / Interleukin-6 Protein (Native)
Mouse IL6ST / CD130 Protein Rat IL6 / Interleukin-6 Protein (Native)
Mouse IL6RA / CD126 Protein (His Tag) Rat LIFR Protein (His Tag)
Mouse IL11RA / IL11Rα Protein (His Tag) Cynomolgus IL6 / Interleukin-6 Protein (Native)
OSMR / IL31RB Protein (His Tag) IL11 / Interleukin 11 / IL-11 Protein
CNTFR / CNTFR-alpha Protein (His Tag) LIF Protein (His Tag)
IL11RA / IL11Rα Protein (His Tag) LIF Protein
Mouse LIFR / CD118 Protein (His Tag) Cynomolgus IL6ST / gp130 Protein
Leptin Receptor / LEPR / CD295 Protein (His Tag) Cynomolgus IL6ST / gp130 Protein (His Tag)
Mouse IL6ST / gp130 / CD130 Protein (His Tag) IL6ST / gp130 / CD130 Protein
CNTF Protein (His Tag) Canine IL11RA / IL-11RA / IL11Rα Protein
Rat gp130 / IL6ST / CD130 Protein Mouse Oncostatin M / OSM Protein (Native)
Rat CNTFR / CNTFR-alpha Protein (His Tag) Mouse CNTF / Ciliary Neurotrophic Factor Protein (His Tag)
Rat gp130 / IL6ST / CD130 Protein (His Tag) NNT1 / CLCF1 / CLC Protein
Rat CNTF / Ciliary Neurotrophic Factor Protein (Native)  

All IL-6 Antibodies

Product name Product name
CD114 / G-CSFR / GCSFR Antibody IL-6 Antibody
IL6R / CD126 Antibody (Mouse Monoclonal Antibody) OSMR / IL-31RB Antibody
IL6R / CD126 Antibody CNTF Antibody
IL6 / IFNB2 Antibody CNTF Antibody
IL6 / IFNB2 Antibody Leptin Receptor / CD295 / LEPR Antibody
IL6 / IFNB2 Antibody (Antigen Affinity Purified) CNTF Antibody (Antigen Affinity Purified)
IL6R / CD126 Antibody (Antigen Affinity Purified) CNTFR Antibody (Antigen Affinity Purified)
LIFR / CD118 Antibody Leptin Receptor / CD295 / LEPR Antibody (Antigen Affinity Purified)
LIFR / CD118 Antibody (Antigen Affinity Purified) gp130 / CD130 / IL6ST Antibody
IL6RA / CD126 Antibody gp130 / CD130 / IL6ST Antibody (Antigen Affinity Purified)
LIFR / CD118 Antibody (Mouse Monoclonal Antibody) CNTF Antibody
Leptin / LEP Antibody CNTF Antibody (Antigen Affinity Purified)
IL6RA / CD126 Antibody (Antigen Affinity Purified) CNTFR Antibody
Leptin / LEP Antibody (Antigen Affinity Purified) LIFR Antibody
LIFR / CD118 Antibody (Rabbit Monoclonal Antibody) gp130 / CD130 / IL6ST Antibody
OSMR / IL31RB Antibody gp130 / CD130 / IL6ST Antibody
OSMR / IL31RB Antibody (Antigen Affinity Purified) Oncostatin M / OSM Antibody (Antigen Affinity Purified)
IL6RA / CD126 Antibody OSMR / IL-31RB Antibody
OSMR / IL31RB Antibody IL-6R / CD126 Antibody ( FITC )
Leptin / LEP Antibody IL-6R / CD126 Antibody ( PE )
CNTFR / CNTFR-alpha Antibody gp130 / CD130 / IL6ST Antibody
CNTFR / CNTFR-alpha Antibody (Antigen Affinity Purified) Leptin Receptor / CD295 / LEPR Antibody
LIFR / CD118 Antibody G-CSFR / CD114 Antibody ( PE )
LIFR / CD118 Antibody (Antigen Affinity Purified) Oncostatin M / OSM Antibody
IL11RA / IL11Rα Antibody  
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"