IL5RA Protein (CD125 Protein)

Interleukin 5 Receptor, Alpha (Cluster of Differentiation 125);

IL5RA Products

IL5RA Protein, Recombinant

Molecule	Species	Description	Cat. No
IL5RA/CD125	Human	IL5RA Protein, Recombinant	10392-H08H

IL5RA cDNA Clone

Molecule	Species	Description	Cat. No
IL5RA/CD125	Human	Homo sapiens IL5RA(variant2) cDNA Clone	HG10392-M
IL5RA/CD125	Human	Homo sapiens IL5RA(variant1) cDNA Clone	HG10391-M

IL5RA Related Areas

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL5RA/CD125

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL5RA/CD125

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL5RA/CD125

IL5RA Alternative Names

IL5RA, CD125, CDw125, HSIL5R3, IL5R, MGC26560 [Homo sapiens]

Il5ra, CD125, CDw125, Il5r [Mus musculus]

IL5RA Background

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. IL5RA (CD125) is a T-cell-derived cytokine which is particularly important in the development of asthma for the lerminal differentiation, activation and survival of committed cosinophil precursors.

IL5RA Related Studies

1. Isobe M, et al. (1992) Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14(3): 755-8.
2. Cheong HS, et al. (2005) Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. J Hum Genet. 50(12): 628-34.
3. Isobe M, et al. (1992) Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14(3): 755-8.