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IL-5/IL5 / Interleukin 5  Protein, Antibody, ELISA Kit, cDNA Clone

Description:   
Expression host: E. coli  
  • Slide 1
15673-HNCE-5
15673-HNCE-20
15673-HNCE-100
5 µg 
20 µg 
100 µg 
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Description: Active  
Expression host: Baculovirus-Insect Cells  
  • Slide 1
51068-M08B-5
51068-M08B-20
51068-M08B-100
5 µg 
20 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
  • Slide 1
70019-D08B-5
70019-D08B-20
70019-D08B-100
5 µg 
20 µg 
100 µg 
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IL-5/IL5 / Interleukin 5 Related Area

IL-5/IL5 / Interleukin 5 Related Pathways

    IL-5/IL5 / Interleukin 5 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    IL-5/IL5 / Interleukin 5 Summary & Protein Information

    IL-5/IL5 / Interleukin 5 Background

    Gene Summary: The protein encoded by IL5 gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL5 gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subunit structure: Homodimer; disulfide-linked.
    Subcellular location: Secreted.
    Sequence similarity: Belongs to the IL-5 family.
    General information above from UniProt

    Interleukin 5 (IL-5) is a member of the interleukin family with length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins / signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered as a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival.

    IL-5/IL5 / Interleukin 5 Alternative Name

    EDF,TRF,IL-5, [homo-sapiens]
    TRF,EDF,IL-5, [human]
    RP23-239O19.2,Il-5, [mouse]
    Il-5, [mus-musculus]

    IL-5/IL5 / Interleukin 5 Related Studies

  • Milburn MV, et al. (1993) A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 363(6425): 172-176.
  • Lee JS, et al. (1989) The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11. Somat Cell Mol Genet. 15(2): 143-152.
  • Woodcock JM, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13 (21): 5176-85.
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