IL5 / Interleukin 5 Protein

Interleukin 5

IL5 / Interleukin 5 Products

IL5 / Interleukin 5 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL5 / Interleukin 5	Mouse	IL5 Protein, Recombinant	51068-M08B
IL5 / Interleukin 5	Canine	IL5 Protein, Recombinant	70019-D08B

IL5 / Interleukin 5 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL5 / Interleukin 5	Mouse	IL5 cDNA Clone / ORF Clone	MG51068-G
IL5 / Interleukin 5	Canine	IL5 cDNA Clone / ORF Clone	DG70019-G

IL5 / Interleukin 5 Related Areas

Immunology>>Adaptive Immunity>>B Cell>>IL-5/IL5

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-5/IL5

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-5/IL5

IL5 / Interleukin 5 Alternative Names

EDF, IL-5, TRF[Homo sapiens]

RP23-239O19.2, Il-5[Mus musculus]

IL5 / Interleukin 5 Background

Interleukin 5 (IL-5) is a member of the interleukin family with length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins / signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered as a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival.

IL5 / Interleukin 5 Related Studies

Milburn MV, et al. (1993) A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 363(6425): 172-176.
Lee JS, et al. (1989) The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11. Somat Cell Mol Genet. 15(2): 143-152.
Woodcock JM, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13 (21): 5176-85.