IL37 / IL1F7 / IL-1H4 Protein

Interleukin 37l

IL1F7 / IL37 / IL-1H4 Products

IL1F7 / IL37 / IL-1H4 Protein, Recombinant

Molecule	Species	Description	Cat. No
IL1F7 / IL37 / IL-1H4	Human	IL37 / IL1F7 / IL-1H4 Protein, Recombinant, Native	10155-HNAE

IL1F7 / IL37 / IL-1H4 Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL1F7 / IL37 / IL-1H4

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>> IL1F7 / IL37 / IL-1H4

Cancer>>Growth Factor & Receptor>>Other>> IL1F7 / IL37 / IL-1H4

IL1F7 / IL37 / IL-1H4 Alternative Names

FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1 [Homo sapiens]

IL1F7 / IL37 / IL-1H4 Background

Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases and / or cancer. Through constructing an adenoviral vector that allows high level expression in murine and human cells, it has been demonstrated that the ability of adenovirus-mediated gene transfer of IL1F7 to induce an IL-12- and Fas ligand-dependent anti-tumor response. Complete inhibition of tumor growth was observed following multiple injections of IL1F7 in the most animals. These results suggest that IL1F7 could play a role in both innate and adaptive immune responses, similar to IL-18. Moreover, IL1F7 could be useful for cancer gene therapy. 

IL1F7 / IL37 / IL-1H4 Related Studies

1. Gao W, et al. (2003) Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol. 170 (1): 107-13.
2. Bufler P, et al. (2002) A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci. 99 (21): 13723-8.
3. Kumar S, et al. (2002) Interleukin-1F7B (IL-1H4 / IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine. 18 (2): 61-71.