All IL-37 reagents are produced in house and quality controlled, including 3 IL-37 Antibody, 1 IL-37 Gene, 1 IL-37 Protein, 1 IL-37 qPCR. All IL-37 reagents are ready to use.
Recombinant IL-37 proteins are expressed by E. coli with fusion tags as Native.
IL-37antibodies are validated with different applications, which are ELISA.
IL-37cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL-37 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases and / or cancer. Through constructing an adenoviral vector that allows high level expression in murine and human cells, it has been demonstrated that the ability of adenovirus-mediated gene transfer of IL1F7 to induce an IL-12- and Fas ligand-dependent anti-tumor response. Complete inhibition of tumor growth was observed following multiple injections of IL1F7 in the most animals. These results suggest that IL1F7 could play a role in both innate and adaptive immune responses, similar to IL-18. Moreover, IL1F7 could be useful for cancer gene therapy.