IL37 / IL1F7 / IL-1H4 Protein (Native)

Interleukin 37l Protein Datasheet

IL37 / IL1F7 / IL-1H4 Protein Product Information

• Synonym: IL37,FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
• Protein Construction: A DNA sequence encoding the mature form of human IL1F7 isoform A (Q9NZH6-2) (Lys 27-Asp 192 ) was expressed and purified, with an initial Met.
• Source: Human
• Expression Host: E.coli

IL37 / IL1F7 / IL-1H4 Protein QC Testing

• Purity: > 96 % as determined by SDS-PAGE.
• Endotoxin: Please contact us for more information.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Met
• Molecular Mass: The recombinant human IL1F7 consisting of 167 amino acids and has a calculated molecular mass of 18.7 KDa. It migrates as an 25 kDa band in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from 0.2μm filtered solution of PBS, pH 7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: IL37 / IL1F7 / IL-1H4 protein

IL37 / IL1F7 / IL-1H4 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL37 / IL1F7 / IL-1H4 Protein Description

Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases and / or cancer. Through constructing an adenoviral vector that allows high level expression in murine and human cells, it has been demonstrated that the ability of adenovirus-mediated gene transfer of IL1F7 to induce an IL-12- and Fas ligand-dependent anti-tumor response. Complete inhibition of tumor growth was observed following multiple injections of IL1F7 in the most animals. These results suggest that IL1F7 could play a role in both innate and adaptive immune responses, similar to IL-18. Moreover, IL1F7 could be useful for cancer gene therapy.

References

1. Gao W. et al., 2003, J Immunol. 170 (1): 107-13.
2. Bufler P. et al., 2002, Proc Natl Acad Sci. 99 (21): 13723-8.
3. Kumar S. et al., 2002, Cytokine. 18 (2): 61-71.