All IL36B reagents are produced in house and quality controlled, including 7 IL36B Antibody, 26 IL36B Gene, 3 IL36B Protein, 2 IL36B qPCR. All IL36B reagents are ready to use.
Recombinant IL36B proteins are expressed by E. coli with fusion tags as Native, N-His.
IL36Bantibodies are validated with different applications, which are WB, ELISA, IHC-P.
IL36BcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL36B of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.