Anti-IL36B Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human IL36B / IL1F8 protein (Catalog#10579-HNAE)
Produced in rabbits immunized with purified, recombinant Human IL36B / IL1F8 (rh IL36B / IL1F8; Catalog#10579-HNAE; Q9NZH7-2; Met1-Glu157). IL36B / IL1F8 specific IgG was purified by Human IL36B / IL1F8 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL36B Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-IL36B Antibody Alternative Names
Anti-FIL1 Antibody;Anti-FIL1-(ETA) Antibody;Anti-FIL1H Antibody;Anti-FILI-(ETA) Antibody;Anti-IL-1F8 Antibody;Anti-IL-1H2 Antibody;Anti-IL1-ETA Antibody;Anti-IL1F8 Antibody;Anti-IL1H2 Antibody;Anti-IL36B Antibody
IL36B Background Information
Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.
interleukin 36, beta
Magne D, et al. (2006) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Arthritis Research & Therapy. 8: R80.Smith DE, et al. (2000) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. The Journal of Biological Chemistry. 275: 1169-75.