Rat IL23R / IL23 Receptor Protein (Cytokine)

Interleukin 23 receptor Protein Datasheet

IL23R / IL23 Receptor Protein Product Information

• Synonym: IL23R
• Protein Construction: A DNA sequence encoding the rat IL23R (Met1-Asp367) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
• Source: Rat
• Expression Host: Human Cells

IL23R / IL23 Receptor Protein QC Testing

• Purity: > 95% as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Met
• Molecular Mass: The recombinant rat IL23R/Fc is a disulfide-linked homodimer. The reduced monomer comprises 608 amino acids and has a predicted molecular mass of 69.4 kDa. The apparent molecular mass of the protein is approximately 92-110 kDa in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS, pH 7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: IL23R / IL23 Receptor protein

IL23R / IL23 Receptor Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL23R / IL23 Receptor Protein Description

IL23R, also known as IL23Receptor, is a member of the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

References

1. Duerr RH. et al., 2006, Science. 314 (5804): 1461-3.
2. Cargill M. et al., 2007, Am J Hum Genet. 80 (2): 273-90.
3. Dubinsky MC. et al., 2007, Inflamm Bowel Dis. 13 (5): 511-5.
4. Tremelling M. et al., 2007, Gastroenterology. 132 (5): 1657-64.