IL23 Receptor Protein, Rat, Recombinant (Fc Tag)

Cat: 80395-R02H
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IL23 Receptor Protein, Rat, Recombinant (Fc Tag) Product Information
Purity
(75.1+16.6) as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Measured by its ability to bind recombinant mouse IL12Bh (m)+mIL23Ah (Cat:CT028-M08H) in a functional ELISA.
Protein Construction
A DNA sequence encoding the rat IL23R (Met1-Asp367) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Expressed Host
HEK293 Cells
Species
Rat
Predicted N Terminal
Met
Molecule Mass
The recombinant rat IL23R/Fc is a disulfide-linked homodimer. The reduced monomer comprises 608 amino acids and has a predicted molecular mass of 69.4 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL23 Receptor Protein, Rat, Recombinant (Fc Tag) in SDS-PAGE
Rat IL23R / IL23 Receptor Protein 12615
IL23 Receptor Background Information

IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

Full Name
interleukin 23 receptor
References
  • Duerr RH, et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 314(5804):1461-3.
  • Cargill M, et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 80(2):273-90.
  • Dubinsky MC, et al. (2007) IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm Bowel Dis. 13(5):511-5.
  • Tremelling M, et al. (2007) IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology. 132(5):1657-64.
  • Other IL23 Receptor Proteins

    Cynomolgus IL23 Receptor Proteins

    Product Name Cat.No.
    IL23 Receptor Protein, Cynomolgus, Recombinant (Fc Tag) 90123-C02H

    Rat IL23 Receptor Proteins

    Product Name Cat.No.
    IL23 Receptor Protein, Rat, Recombinant (ECD, His Tag) 80395-R08H

    Human IL23 Receptor Proteins

    Product Name Cat.No.
    IL23 Receptor Protein, Human, Recombinant (Fc Tag) 13840-H02H
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