IL20RB

IL20RB belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family. IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20.

IL20RB Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>> IL20RB

IL20RB Alternative Names

hCG_2022374, DIRS1, FNDC6, IL-20R2, MGC34923, IL-20 receptor subunit beta, IL-20R-beta, IL-20RB, fibronectin type III domain containing 6, interleukin-20 receptor II, interleukin-20 receptor subunit beta [Homo sapiens]

AV228068, Fndc6, Gm186, Il20R2, MGC130209, fibronectin type III domain containing 6 [Mus musculus]

Summaries for IL20RB

Entrez Gene summary for IL20RB:

IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619)

OMIM - description for IL20RB:

IL20RB and IL20RA (605620) form a heterodimeric receptor for interleukin-20 (IL20; 605619)

Wikipedia summary for IL20RB:

Interleukin-20 receptor beta chain is a protein that in humans is encoded by the IL20RB gene

Human IL20RB Protein General Information

 

• Protein names: Recommended name: Interleukin-20 receptor subunit beta Short name=IL-20 receptor subunit beta Short name=IL-20R-beta Short name=IL-20RB
• Sequence length: 311 AA.
• Domain: Repeat Signal Transmembrane Transmembrane helix
• Sequence similarities: Belongs to the type II cytokine receptor family. Contains 2 fibronectin type-III domains.
• Subunit structure: Heterodimer with IL20RA and heterodimer with IL22RA1.
• Subcellular location: Membrane; Single-pass type I membrane protein
• Tissue specificity: Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin

General information above from UniProt

Function for IL20RB Protein

UniProtKB:

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

Genatlas: