Rat IL20RB Protein (His Tag) (Cytokine)

Interleukin 20 receptor beta Protein Datasheet

IL20RB Protein Product Information

• Synonym: IL20RB
• Protein Construction: A DNA sequence encoding the rat IL20RB (B8K1X9) (Met1-Pro227) was expressed, fused with a polyhistidine tag at the C-terminus.
• Source: Rat
• Expression Host: Human Cells

IL20RB Protein QC Testing

• Purity: > 91 % as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Phe 22
• Molecular Mass: The recombinant ratIL20RB comprises 217 amino acids and predicts a molecular mass of 24.6 kDa. The apparent molecular mass of the ratIL20RB is approximately 32-36 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: IL20RB protein

IL20RB Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL20RB Protein Description

IL20RB contains 2 fibronectin type-III domains and belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are heterodimers or multimers with a high and a low affinity component. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family. IL20RB is widely expressed with highest levels in skin and testis and highly expressed in psoriatic skin. The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

References

1. Zhu H. et al., 2009, Hepatobiliary Pancreat Dis Int. 8 (4): 402-6.
2. Logsdon NJ. et al., 2012, Acta Crystallogr Sect F Struct Biol Cryst Commun. 68 (1): 89-92.
3. Kingo K. et al., 2008, Genes Immun. 9 (5): 445-51.