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IL20RA/IL-20RA Protein, Antibody, ELISA Kit, cDNA Clone

IL20RA/IL-20RA Related Areas

IL20RA/IL-20RA Related Pathways

IL20RA/IL-20RA Related Product

IL20RA/IL-20RA Summary & Protein Information

IL20RA/IL-20RA Related Information

IL20RA/IL-20RA Background

Gene Summary: The protein encoded by IL20RA gene is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA gene and IL20B are highly expressed in skin. The expression of both genes is found to be upregulated in Psoriasis. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subunit structure: Heterodimer with IL20RB and heterodimer with IL10RB.
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity).
Tissue specificity: Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.
Sequence similarity: Belongs to the type II cytokine receptor family.
Contains 2 fibronectin type-III domains.C
General information above from UniProt

Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

IL20RA/IL-20RA Alternative Name

FLJ40993,IL-20R1,IL20RA,RP11-204P2.1,ZCYTOR7, [human]
E230031K19,Il20ra, [mouse]

IL20RA/IL-20RA Related Studies

  • Parrish-Novak J, et al. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49): 47517-23.
  • Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5): 445-51.
  • Blumberg H, et al. (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104(1): 9-19.
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