Anti-IL20RA Antibody

Cat: 10397-R038
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All IL20RA Reagents
Anti-IL20RA Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-IL20RA Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human IL20RA
No cross-reactivity in ELISA with Human IFNgR1 Human IL10RB
Immunogen
Recombinant Human IL20RA / IL-20RA protein (Catalog#10397-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL20RA / IL-20RA (rh IL20RA / IL-20RA; Catalog#10397-H08H; NP_055247.21; Met 1-Lys 250).
Source
Monoclonal Rabbit IgG Clone #038
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL20RA Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL20RA Antibody (Rabbit Monoclonal antibody) Images
Human IL20RA/IL-20RA Immunohistochemistry(IHC) 4001
Immunochemical staining of human IL20Ra in human skin with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to stratified squamous epithelium.
Anti-IL20RA Antibody Alternative Names
Anti-CRF2-8 Antibody;Anti-IL-20R-alpha Antibody;Anti-IL-20R1 Antibody;Anti-IL-20RA Antibody
IL20RA Background Information

Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

Full Name
interleukin 20 receptor, alpha
References
  • Parrish-Novak J, et al. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49): 47517-23.
  • Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5): 445-51.
  • Blumberg H, et al. (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104(1): 9-19.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL20RA Antibody Rabbit Polyclonal IHC-P 106724-T08
    Anti-IL20RA Antibody Rabbit Monoclonal ELISA,IHC-P 10397-R024
    Anti-IL20RA Antibody Mouse Monoclonal ELISA 10397-MM06
    Anti-IL20RA Antibody Rabbit Polyclonal ELISA 10397-RP02
    Anti-IL20RA Antibody Rabbit Polyclonal ELISA 10397-RP01
    Anti-IL20RA Antibody Mouse Monoclonal ELISA(Cap) 10397-MM02
    Anti-IL20RA Antibody Rabbit Polyclonal ELISA 10397-T16
    Anti-IL20RA Antibody Rabbit Monoclonal ELISA 10397-R005
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