IL2 / IL-2 / Interleukin-2 Protein

Interleukin 21

IL-21 Products

IL-21 Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-21/IL21	Human	IL-21/IL-21 Protein, Recombinant, with Native	10584-HNAE
IL-21/IL21	Mouse	IL21 / Interleukin 21 Protein, Recombinant, with Native	50137-MNAE
IL-21/IL21	Canine	IL21 / Interleukin 21 Protein, Recombinant, with Native	70016-DNAE

  10584-HNAE:  Measured by its ability to bind human IL-21R in a functional ELISA.

IL-21 cDNA Clone

Molecule	Species	Description	Cat. No
IL-21/IL21	Human	IL21 cDNA Clone / ORF Clone	HG10584-M
IL-21/IL21	Mouse	IL21 cDNA Clone / ORF Clone	MG50137-M
IL-21/IL21	Canine	IL21 cDNA Clone / ORF Clone	CG70016-G
IL-21/IL21	Rat	IL21 cDNA Clone / ORF Clone	RG80200-G

IL-21 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-21/IL21

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-21/IL21

IL-21 Alternative Names

IL-21, IL21, Za11 [Homo sapiens]

IL-21, Il21, DN-452A22.7 [Mus musculus]

IL-21 Background

IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).

IL-21 Related Studies

1. Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178 (5): 2827-34.
2. Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282 (48): 34605-10.
3. Parrish-Novak J, et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72 (5): 856-63.
4. Kuchen S, et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179 (9): 5886-96.