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Rat IL-1RA / IL1RN Protein (Fc Tag)
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Rat IL-1RA / IL1RN Protein (Fc Tag) (Cytokine) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80073-R01H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Interleukin 1 receptor antagonist Protein Datasheet

 

IL1RN / IL1RA Protein Price Inquiry ( Available Sizes )

IL1RN / IL1RA Protein Product Information

Synonym : IL1RN, Il-1ra
Protein Construction:

A DNA sequence encoding the rat IL1RN(P25086)(His27-Gln178) was expressed, fused with Fc region of human IgG1 at the N-terminus.

Source: Rat
Expression Host: Human Cells

IL1RN / IL1RA Protein QC Testing

Purity: > 85 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

IL1RN / IL1RA protein

Bio-activity:

Immobilized rat IL1R1-His (Cat:80028-R08H) at 10 μg/ml (100 μl/well) can bind rat Fc-IL1RN, The EC50 of rat Fc-IL1RN is 5.1-11.9 ng/ml.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Glu
Molecular Mass:

The recombinant rat IL1RN comprises 412 amino acids and predicts a molecular mass of 45.8 kDa. The apparent molecular mass of  the recombinant protein is approximately 47 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

IL1RN / IL1RA Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL1RN / IL1RA Protein Related Products & Topics

Related Areas:

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1RA/IL-1F3

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL-1RA/IL-1F3

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IL-1RA/IL-1F3 Human IL-1RA/IL-1F3/Fc Protein, Recombinant 10123-H01H
IL-1RA/IL-1F3 Human IL-1RA/IL-1F3 Protein, Recombinant, with Native 10123-HNAE
IL-1RA/IL-1F3 Rat IL1RN / IL1RA Protein, Recombinant 80073-R01H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Huma
IL-1RA/IL-1F3
WB, ELISA IL-1RA/IL-1F3 Antibody, Rabbit MAb 10123-R001
Huma
IL-1RA/IL-1F3
WB, FCM IL-1RA Antibody ( FITC ) 10123-R004-F
Huma
IL-1RA/IL-1F3
WB, ELISA IL-1RA/IL-1F3 Antibody, Mouse MAb 10123-MM12

IL1RN / IL1RA Protein Description

IL1 is an important prototypic pro-inflammatory cytokine that affects multiple cell types, often in concert with another cytokine, tumor necrosis factor (TNF). There are two forms of IL1, IL1α. and IL1β, whose function are mediated by the two specific receptors on the cell surfaces. The IL1 receptor antagonist (IL1RA), formerly called the IL1 inhibitor, is a member of the IL1 cytokine family which binds to the same receptor (IL1R) as IL1, and thus prevents IL1 from signal transduction without interaction with the IL1 molecules. In terms of protein similarities,IL1RA is more closely related to IL1β than it is to IL1α. IL1RA modulates a variety of IL1-related immune and inflammatory responses, and accordingly, the balance between IL1 and IL1Ra in local tissues plays an important role in the susceptibility to and severity of many diseases. IL1RA is suggested to have possible therapeutic applications in treatment of sepsis, rheumatoid arthritis, and chronic myelogenous leukemia. Four alternatively spliced transcript variants encoding distinct isoforms have been identified, and the isoform 1 of IL1RA is secreted from monocytes, macrophages, neutrophils, and other cells.

References

  1. Haskill S. et al., 1991, Proc Natl Acad Sci. 88: 3681-5.
  2. Sehouli J. et al., 2002, Anticancer Res. 22: 3421-4.
  3. Arend WP. e t al., 1998, Annu Rev Immunol. 16: 27-55.
  4. Dinarello CA. et al., 1997, Cytokine Growth Factor Rev. 8: 253-65.
 

All IL-1 Proteins

Product name Product name
IL18 Protein (Native) IL-1 alpha / IL1A / IL1F1 Protein
IL18BPa Protein Mouse IL1R1 / CD121a Protein (His Tag)
IL18BPa Protein (His Tag) Cynomolgus IL-1 beta / IL1B Protein (Native)
IL1F5 / IL36RN Protein (Native) IL36B / IL1F8 Protein (Native)
IL1R2 / CD121b Protein IL1F6 / IL36A Protein (Native)
IL1RL1 / DER4 Protein Mouse IL-1R8 / IL1RAPL1 Protein
IL1RL1 / DER4 Protein Canine IL-1 beta / IL1B Protein (Native)
IL1R9 Protein IL36G / IL1F9 Protein (Native)
IL1RA / IL1F3 Protein Mouse IL1F8 / IL36b Protein Native
IL1RA / IL1F3 Protein (Native) IL37 / IL1F7 / IL-1H4 Protein Native
IL-1 alpha / IL1A / IL1F1 Protein Mouse IL1R1 / CD121a Protein
IL33 / Interleukin-33 / NF-HEV Protein (Native) Canine IL33 / Interleukin-33 / NF-HEV Protein (Native)
Mouse IL-18R1 Protein IL36B / IL1F8 Protein (His Tag)
IL-1R8 Protein IL1F6 / IL36A Protein (His Tag)
Mouse SIGIRR Protein Rat IL18R1 Protein
IL1R8 Protein (His Tag) Rat IL1R2 / IL1RB / CD121b Protein (His Tag)
IL1R3 Protein IL36G / IL1F9 (aa 18-169) Protein (His Tag)
IL1R1 / CD121a Protein IL36G / IL1F9 (aa 18-169) Protein
IL1R1 / CD121a Protein (His Tag) IL1F6 / IL36 (aa 6-158) Protein
IL-1 beta / IL1B Protein (Native) Mouse IL-18 Protein (Native)
Mouse IL18BP Protein (His Tag) Mouse IL1R2 / CD121b Protein
IL18RAP / IL1R7 Protein Mouse IL1R2 / CD121b Protein (His Tag)
IL18R1 / CD218a Protein (His Tag) Rat IL1RN / IL1RA Protein
IL1R3 / IL1RAP Protein (His Tag) Cynomolgus IL18RAP Protein
IL18R1 / CD218a Protein Cynomolgus IL18RAP Protein (His Tag)
IL1RL1 / ST2 Protein (His Tag) Rat IL1R2 / IL1RB / CD121b Protein
IL1R2 / IL1RB / CD121b Protein (His Tag) Cynomolgus IL1R2 / IL1RB Protein
Mouse IL18R1 / CD218a Protein (His Tag) Mouse IL18 / IL-18 Protein
IL18RAP / IL1R7 Protein (His Tag) IL18 / Interleukin 18 / IGIF Protein (GST Tag)
Mouse IL-1 alpha / IL1A / IL1F1 Protein (Native) IL1R1 / CD121a Protein
Mouse IL1F5 / IL1RP3 Protein (Native) IL1R2 / IL1RB / CD121b Protein
IL1R9 / IL1RAPL2 / IL1 Receptor 9 Protein (His Tag) SIGIRR / TIR8 Protein
Rat IL-1 beta / IL1B ( pro form ) Protein (His Tag) Cynomolgus IL1R1 Protein
SIGIRR / TIR8 Protein (His Tag) Cynomolgus IL1R1 Protein (His Tag)
Cynomolgus IL-18 / IL-1F4 Protein (His Tag) Canine IL18R1 Protein
Mouse IL-1F6 / IL-1 epsilon Protein (Native) Canine IL1R2 / IL1RB Protein
IL-1 beta / IL1B (pro form) Protein (His Tag) Rat IL18R1 Protein (His Tag)
Rat IL1R1 / CD121a Protein (His Tag) Mouse IL36G / IL1F9 Protein (His Tag)
Mouse IL-1 beta / IL1B Protein (Native) Cynomolgus IL18R1 Protein
Rat IL1R1 / CD121a Protein Rabbit IL-1 beta / IL1B Protein
IL1RL1 / ST2 (isoform A) Protein (His Tag) Cynomolgus IL18R1 Protein (His Tag)
Rat IL-1 beta / IL1B (mature form) Protein (Native)  

All IL-1 Antibodies

Product name Product name
IL1RL1 / ST2 Antibody (Mouse Monoclonal Antibody) IL-18 Antibody (Antigen Affinity Purified)
IL1RL1 / ST2 Antibody SIGIRR / TIR8 Antibody
IL33 / Interleukin-33 / NF-HEV Antibody (Mouse Monoclonal Antibody) SIGIRR / TIR8 Antibody (Antigen Affinity Purified)
IL33 / Interleukin-33 / NF-HEV Antibody IL18 / Interleukin-18 Antibody
IL18BP / IL18BPa Antibody (Mouse Monoclonal Antibody) IL-1RA Antibody
IL18BP / IL18BPa Antibody IL-1R8 / IL1RAPL1 Antibody
IL18BP / IL18BPa Antibody IL-1R2 / CD121b Antibody
IL18BP / IL-18BP Antibody IL-1R9 / IL1RAPL2 Antibody (Antigen Affinity Purified)
IL18BP / IL18BPa Antibody (Antigen Affinity Purified) IL-1 beta / IL1B Antibody (Antigen Affinity Purified)
IL1R1 / CD121a Antibody IL-1F6 Antibody (Antigen Affinity Purified)
IL1R1 / CD121a Antibody (Antigen Affinity Purified) IL-1R1 / CD121a Antibody (Antigen Affinity Purified)
IL1RL1 / ST2 Antibody (Antigen Affinity Purified) IL-1 beta / IL1B Antibody (Antigen Affinity Purified)
IL18BP / IL-18BP Antibody (Antigen Affinity Purified) IL-33 Antibody
IL1R1 / CD121a Antibody (Mouse Monoclonal Antibody) IL-1RA Antibody (FITC)
IL18R1 / CD218a Antibody IL-1 alpha / IL-1F1 / IL1A Antibody (Antigen Affinity Purified)
IL18R1 / CD218a Antibody (Antigen Affinity Purified) IL18BP / IL18BPa Antibody
IL33 / Interleukin-33 / NF-HEV Antibody IL1F6 / IL36A Antibody
IL33 / Interleukin-33 / NF-HEV Antibody (Antigen Affinity Purified) IL-1 alpha / IL-1F1 / IL1A Antibody
IL1R3 / IL1RAP Antibody IL-1R1 / CD121a Antibody
IL1R2 / IL1RB / CD121b Antibody IL-33 Antibody
IL1R2 / IL1RB / CD121b Antibody (Antigen Affinity Purified) IL-33 Antibody
IL-1 beta / IL1B / IL1F2 Antibody IL-33 Antibody (FITC)
IL-1 beta / IL1B / IL1F2 Antibody (Antigen Affinity Purified) IL1F6 / IL36A Antibody
IL1R1 / CD121a Antibody IL-18 Antibody
IL18R1 / IL1RRP / CD218a Antibody IL37 / IL1F7 / IL-1H4 Antibody
IL18R1 / IL1RRP / CD218a Antibody (Antigen Affinity Purified) IL-1F5 Antibody
IL18R1 / CD218a Antibody IL-1RAcP / IL-1R3 Antibody (FITC)
IL18BP / IL-18BP Antibody IL-1RAcP / IL-1R3 Antibody (PE)
IL18BP / IL-18BP Antibody IL-1RA Antibody (PE)
IL1R2 / IL1RB / CD121b Antibody IL-33 Antibody (PE)
IL1R2 / IL1RB / CD121b Antibody IL-33 Antibody (FITC)
IL1R2 / IL1RB / CD121b Antibody SIGIRR / TIR8 Antibody
IL18R1 / CD218a Antibody IL1R1 / CD121a Antibody
IL1RA / IL1F3 Antibody IL1R1 / CD121a Antibody
IL-1 beta / IL1B / IL1F2 Antibody IL-1 beta / IL1B Antibody
IL18R1 Antibody IL-1 beta / IL1B Antibody
IL1RL1 Antibody IL-1R1 / CD121a Antibody
IL1RL1 Antibody IL-1R1 / CD121a Antibody
IL-1RAcP / IL-1R3 Antibody (Antigen Affinity Purified) IL-1RA Antibody (Antigen Affinity Purified)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"