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IL1RL1 Antibody, Rabbit MAb

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Human IL1RL1/ST2 Antibody Product Information
Immunogen:Recombinant Human IL1RL1 / IL1R4 Protein (Catalog#10105-H08H)
Clone ID:003
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human IL1RL1 / IL1R4 (rh IL1RL1 / IL1R4; Catalog#10105-H08H; Met 1-Phe 328; NP_003847.2).
Human IL1RL1/ST2 Antibody Usage Guide
Specificity:Human IL1RL1 / IL1R4
No cross-reactivity in ELISA with
Human IL1R1
Human IL1R2
Human IL1RA
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL1R4. The detection limit for Human IL1R4 is approximately 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IL1RL1/ST2 Antibody Products
Reactivity: Human  
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    10105-MM09-200
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    Reactivity: Human  
    Application: ELISA  
      10105-RP03-200
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      Reactivity: Human  
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      • Slide 1
      10105-RP01-400
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      IL1RL1/IL‑1 R4 Background

      IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

      Human IL1RL1/IL‑1 R4 References
    • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
    • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.
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      Size / Price
      Catalog: 10105-R003-50
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      Size:
      50 µg
      100 µg
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      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"