Anti-ST2 Antibody

Cat: 10105-R003
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Anti-ST2 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-ST2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human ST2
No cross-reactivity in ELISA with Human IL1R1 Human IL1R2 Human IL1RA
Immunogen
Recombinant Human IL1RL1 / IL1R4 Protein (Catalog#10105-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL1RL1 / IL1R4 (rh IL1RL1 / IL1R4; Catalog#10105-H08H; Met 1-Phe 328; NP_003847.2).
Source
Monoclonal Rabbit IgG Clone #003
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ST2 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ST2 Antibody Alternative Names
Anti-DER4 Antibody;Anti-FIT-1 Antibody;Anti-IL1RL1 Antibody;Anti-IL33R Antibody;Anti-IL‑1 R4 Antibody;Anti-ST2 Antibody;Anti-ST2L Antibody;Anti-ST2V Antibody;Anti-T1 Antibody
ST2 Background Information

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

Full Name
interleukin 1 receptor-like 1
References
  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ST2 Antibody Rabbit Polyclonal ELISA 51143-RP01
    Anti-ST2 Antibody Rabbit Polyclonal WB,ELISA 51143-T48
    Anti-ST2 Antibody Rabbit Monoclonal ELISA 51143-R006
    Anti-ST2 Antibody Rabbit Polyclonal ELISA 10105-RP03
    Anti-ST2 Antibody Mouse Monoclonal ELISA 10105-MM09
    Anti-ST2 Antibody Mouse Monoclonal ELISA(Cap) 10105-MM10
    Anti-ST2 Antibody Mouse Monoclonal ELISA(Det) 10105-MM12
    Anti-ST2 Antibody Rabbit Polyclonal WB,ELISA 10105-RP01
    Anti-ST2 Antibody Rabbit Polyclonal ELISA 10105-T16
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