Anti-ST2 Antibody

Cat: 10105-MM09

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Anti-ST2 Antibody (Mouse Monoclonal antibody) General Information

Product name
Anti-ST2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human ST2
No cross-reactivity in ELISA and WB with
Human IL1R1 / CD121a
Human IL1R2 / IL1RB / CD121b
Human IL1F3 / IL1RA
Human cell lysate (293 cell line)
Immunogen
Recombinant Human IL1RL1 protein (Catalog#10105-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL1RL1 extracellular domain (rh IL1RL1; Catalog#10218-HCCH; Met 1-Phe 328; NP_003847.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #1E5F10D3
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-ST2 Antibody (Mouse Monoclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ST2 Antibody Alternative Names

Anti-DER4 Antibody;Anti-FIT-1 Antibody;Anti-IL1RL1 Antibody;Anti-IL33R Antibody;Anti-IL‑1 R4 Antibody;Anti-ST2 Antibody;Anti-ST2L Antibody;Anti-ST2V Antibody;Anti-T1 Antibody

ST2 Background Information

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

Full Name
interleukin 1 receptor-like 1
References
  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ST2 Antibody Rabbit Polyclonal ELISA 51143-RP01
    Anti-ST2 Antibody Rabbit Polyclonal WB,ELISA 51143-T48
    Anti-ST2 Antibody Rabbit Monoclonal ELISA 51143-R006
    Anti-ST2 Antibody Rabbit Polyclonal ELISA 10105-RP03
    Anti-ST2 Antibody Rabbit Monoclonal ELISA 10105-R003
    Anti-ST2 Antibody Rabbit Polyclonal WB,ELISA 10105-RP01
    Anti-ST2 Antibody Rabbit Polyclonal ELISA 10105-T16
    Anti-ST2 Antibody Mouse Monoclonal ELISA(Cap) 10105-MM10
    Anti-ST2 Antibody Mouse Monoclonal ELISA(Det) 10105-MM12
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