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IL1RL1 / ST2 Antibody, Mouse MAb

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    Human IL1RL1/ST2 Antibody Product Information
    Immunogen:Recombinant Human IL1RL1 protein (Catalog#10105-H08H)
    Clone ID:1E5F10D3
    Ig Type:Mouse IgG1
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL1RL1 extracellular domain (rh IL1RL1; Catalog#10218-HCCH; Met 1-Phe 328; NP_003847.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other IL1RL1/ST2 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10105-RP03-200
      10105-RP03-50
      10105-RP03-100
      200 µg 
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10105-R003-50
        10105-R003-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  WB  
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        10105-RP01-400
        10105-RP01-100
        10105-RP01-200
         
        100 µg 
        200 µg 
        Add to Cart
        IL1RL1/IL‑1 R4 Background

        IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

        Human IL1RL1/IL‑1 R4 References
      • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
      • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.
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        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"