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Mouse IL1R2 Gene cDNA Clone (full-length ORF Clone)

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IL1R2cDNA Clone Product Information
Gene Bank Ref.ID:NM_010555.4
cDNA Size:974
cDNA Description:ORF Clone of Mus musculus interleukin 1 receptor, type II DNA.
Gene Synonym:CD121b, Il1r-2
Species:Mouse
Vector:pGEM-T Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with the Gene Bank Ref. ID sequence.
Shipping Carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Mouse IL1R2 Gene cDNA Clone (full-length ORF Clone) on other vectors
IL-1 Family & Receptor Related Products
Product nameProduct name
Human IL37 / IL1F7 / IL-1H4 ProteinHuman IL-1R9 / IL1RAPL2 Protein (Fc Tag)Human IL-1R9 / IL1RAPL2 Protein (His Tag)Canine IL18R1 Protein (Fc Tag)Canine IL1R2 / IL1RB Protein (Fc Tag)Canine IL-1 beta / IL1B ProteinHuman IL18RAP / IL1R7 Protein (Fc Tag)Human IL18RAP / IL1R7 Protein (His Tag)Rat IL-1 beta / IL1B Protein (pro form, His Tag)Rat IL-1 beta / IL1B Protein (mature form)Rat IL1R1 / CD121a Protein (His & Fc Tag)Rat IL1R1 / CD121a Protein (His Tag)Human IL-1R8 / IL1RAPL1 Protein (Fc Tag)Human IL-1R8 / IL1RAPL1 Protein (His Tag)Mouse IL-1 alpha / IL1A / IL1F1 ProteinRat IL-1RA / IL1RN Protein (Fc Tag)Mouse IL18 / IL-18 ProteinHuman IL18R1 / CD218a Protein (His Tag)Mouse IL-1 beta / IL1B ProteinCynomolgus IL-1 beta / IL1B ProteinRat IL18R1 Protein (Fc Tag)Rat IL18R1 Protein (His Tag)Rat IL1R2 / IL1RB / CD121b Protein (Fc Tag)Rat IL1R2 / IL1RB / CD121b Protein (His Tag)Human IL36B / IL1F8 ProteinMouse IL18RAP / IL1R7 Protein (His Tag)Human IL1RL1 / ST2 Protein (isoform a, His Tag)Mouse IL-18R1 Protein (His & Fc Tag)Mouse IL18R1 / CD218a Protein (His Tag)Mouse IL-1F6 / IL-1 epsilon ProteinHuman IL1F6 / IL36A Protein (His Tag)Human IL1F6 / IL36A ProteinHuman IL1F6 / IL36 Protein (aa 6-158)Canine IL33 / Interleukin-33 / NF-HEV ProteinMouse MKK4 / MEK4 / MAP2K4 Protein (His & GST Tag)Sus scrofa (Pig) IL1B / IL-1 beta ProteinMouse SIGIRR / TIR8 Protein (His & Fc Tag)Rabbit IL-1 beta / IL1B ProteinCynomolgus IL1R1 Protein (Fc Tag)Human IL-1 beta / IL1B ProteinFeline IL1B / IL-1 beta ProteinMouse IL1RL1 / ST2 Protein (Fc Tag)Human IL36B / IL1F8 Protein (His Tag)Cynomolgus IL-18 / IL-1F4 Protein (His Tag)Cynomolgus IL18R1 Protein (His Tag)Cynomolgus IL1R1 Protein (His Tag)Human p38 alpha / MAPK14 Protein (His Tag)Mouse IL1RL1 / ST2 Protein (His Tag)Human JNK1 / MAPK8 Protein (GST Tag)Human MKK6 / MEK6 / MAP2K6 ProteinHuman JNK2 / MAPK9 Protein (His Tag)Cynomolgus IL1R2 / IL1RB Protein (Fc Tag)Cynomolgus IL18R1 Protein (Fc Tag)Cynomolgus IL18RAP Protein (Fc Tag)Cynomolgus IL18RAP Protein (His Tag)Human IL-1 alpha / IL1A / IL1F1 ProteinHuman IL33 / Interleukin-33 / NF-HEV ProteinMouse IL18BP Protein (His Tag)Mouse IL1R1 / CD121a Protein (Fc Tag)Human p38 alpha / MAPK14 Protein (Activated in vitro, His Tag)Mouse IL1R1 / CD121a Protein (His Tag)Human p38 delta / MAPK13 Protein (Activated in vitro, GST Tag)Human IL18R1 / CD218a Protein (His & Fc Tag)Human p38 delta / MAPK13 Protein (GST Tag)Human MKK6 / MEK6 / MAP2K6 Protein (207 Ser/Asp, 211 Thr/Asp, His & GST Tag)Mouse IL-1R8 / IL1RAPL1 Protein (Fc Tag)Human IL18BPa Protein (His & Fc Tag)Human IL18BPa Protein (His Tag)Human MKK6 / MEK6 / MAP2K6 Protein (207 Asp, 211 Asp)Mouse IL1F8 / IL36b ProteinMouse IL1R2 / CD121b Protein (Fc Tag)Mouse IL1R2 / CD121b Protein (His Tag)Human ERK2 / MAPK1 / MAPK2 Protein (GST Tag)Mouse IL36G / IL1F9 Protein (His Tag)Human IKB alpha / NFKBIA Protein (His Tag)Human MKK6 / MEK6 / MAP2K6 Protein (His & GST Tag)Human RELA / Transcription factor p65 / NFkB p65 Protein (aa 1-306, GST Tag)Mouse ERK2 / MAPK1 / MAPK2 Protein (His & GST Tag)Mouse ERK2 / MAPK1 / MAPK2 ProteinHuman p38 alpha / MAPK14 Protein (His Tag)Human p38 alpha / MAPK14 Protein (His Tag)Human SIGIRR / TIR8 Protein (Fc Tag) Human SIGIRR / TIR8 Protein (His Tag)Human MARK3 / CTAK1 / EMK-2 Protein (His & GST Tag)Human IL1RL1 / DER4 Protein (Fc Tag)Human IL1RL1 / ST2 Protein (His Tag)Human IL1RL1 / DER4 ProteinHuman IL1R2 / CD121b Protein (Fc Tag)Human IL1R2 / IL1RB / CD121b Protein (His Tag)Human IL1R2 / IL1RB / CD121b ProteinHuman IL18 / Interleukin 18 / IGIF Protein (GST Tag)Human IL-1RAcP / IL-1R3 Protein (His & Fc Tag)Human IL-1RAcP / IL-1R3 Protein (His Tag)Human IL-1RA / IL1RN Protein (Fc Tag)Human IL-1RA / IL1RN ProteinHuman IL36G / IL1F9 Protein (aa 18-169, His Tag)Human IL36G / IL1F9 ProteinHuman IL36G / IL1F9 Protein (aa 18-169)Human IL1F5 / IL36RN ProteinHuman IL1R1 / CD121a Protein (Fc Tag)Human IL1R1 / CD121a Protein (His Tag)Human IL1R1 / CD121a ProteinHuman IL-1 beta / IL1B Protein (pro form, His Tag)
Background

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

References
  • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
  • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
  • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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