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Cynomolgus IL1R2 / IL1RB Protein (Fc Tag)

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Cynomolgus IL1R2 Protein Product Information
Synonym:IL1R2
Protein Construction:A DNA sequence encoding the cynomolgus IL1R2 (Q8HXR9) (Met1-Glu343) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Species:Cynomolgus
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Cynomolgus IL1R2 Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE
Bio-Activity:Measured by its binding ability in a functional ELISA.
Immobilized Cynomolgus IL1R2-Fc at 10 μg/ml (100 μl/well) can bind biotinylated human IL1B-His (Cat:10139-H07E), The EC50 of biotinylated human IL1B-His (Cat:10139-H07E) is 11.8-27.4 ng/ml.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Phe 14
Molecule Mass:The recombinant cynomolgus IL1R2 is a disulfide-linked homodimer. The reduced monomer comprises 571 amino acids and has a calculated molecular mass of 64.7 KDa.The apparent molecular mass of the protein is approximately 75-89 KDa respectively in SDS-PAGE.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Cynomolgus IL1R2 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Cynomolgus IL1R2 Protein SDS-PAGE
Cynomolgus IL1R2 / IL1RB Protein (Fc Tag) SDS-PAGE
Cynomolgus IL1R2 / IL1RB Protein (Fc Tag) SDS-PAGE
Other IL1R2 Recombinant Protein Products
90120-C02H
IL-1R2/CD121b Background

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

Cynomolgus IL-1R2/CD121b References
  • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
  • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
  • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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    Catalog: 90120-C02H-50
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    • Cynomolgus IL1R2 / IL1RB Protein (Fc Tag) SDS-PAGE
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        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"