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Mouse IL1R2 / CD121b Protein (Fc Tag)
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Mouse IL1R2 / CD121b Protein (Fc Tag) (Cytokine) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
51090-M02H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Interleukin 1 receptor, type II Protein Datasheet

 

IL1R2 / CD121b Protein Price Inquiry ( Available Sizes )

IL1R2 / CD121b Protein Product Information

Synonym : IL1R2, Il-1r2, Il1rb
Protein Construction:

A DNA sequence encoding the mouse IL1R2 (P27931) (Met1- Glu355) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Source: Mouse
Expression Host: Human Cells

IL1R2 / CD121b Protein QC Testing

Purity: > 85% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

IL1R2 / CD121b protein

Bio-activity:

Measured by its ability to bind biotinylated recombinant human IL1α (Cat:10128-HNCH) in a functional ELISA.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Phe 14
Molecular Mass:

The recombinant mouse IL1R2 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 583 amino acids and has a predicted molecular mass of 65.1 kDa. The apparent molecular mass of the protein is approximately 91 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

IL1R2 / CD121b Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL1R2 / CD121b Protein Related Products & Topics

Related Areas:

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1R2/ CD121b

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 Superfamily and IL-1R/TLR Family>>IL-1R2/ CD121b

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> IL-1R2/CD121b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>IL-1R2/CD121b

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IL-1R2/CD121b Human IL-1R2/CD121b/Fc Protein, Recombinant 10111-H02H
IL-1R2/CD121b Human IL-1R2/CD121b Protein, Recombinant 10111-H08H
IL-1R2/CD121b Mouse IL1R2 / CD121b Protein, Recombinant 51090-M02H
IL-1R2/CD121b Mouse IL1R2 / CD121b Protein, Recombinant 51090-M08H
IL-1R2/CD121b Rat IL1R2 / IL1RB / CD121b Protein, Recombinant 80196-R02H
IL-1R2/CD121b Rat IL1R2 / IL1RB / CD121b Protein, Recombinant 80196-R08H
IL-1R2 Cynomolgus IL1R2 / IL1RB Protein, Recombinant 90120-C02H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
IL-1R2/CD121b
WB IL-1R2/CD121b Antibody, Mouse Mab 10111-MM09
Human
IL-1R2/CD121b
WB, ELISA IL-1R2/CD121b Antibody, Rabbit MAb 10111-R020
Human
IL-1R2/CD121b
WB, ELISA IL-1R2/CD121b Antibody, Rabbit PAb 10111-RP01
Human
IL-1R2/CD121b
WB, ELISA IL-1R2/CD121b Antibody, Rabbit PAb (Antigen Affinity Purified) 10111-RP02
Human
IL-1R2/CD121b
WB, ELISA IL-1R2/CD121b Antibody, Mouse MAb 10111-MM04

IL1R2 / CD121b Protein Description

The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). A closely related receptor-like chain IL1R accessory protein (IL1RAcP) has been reported to heterodimerize with the IL1RI to form the signal transduction complex which appears to mediate all the known IL1 signal processes. IL1RII structurally consisting of a ligand binding portion comprised of three Ig -like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Like the IL1RI, the human IL1RII can bind all three forms of IL1 (IL1 alpha, IL1 beta and IL1ra) but does not transmit IL1 signals. In addition to the membrane-bound form, IL1RII also exists as the soluble form, and either acts as a decoy receptor that inhibits IL1 action by blocking the binding of IL1 to the type I receptor complex. Furthermore, IL4 is reported to antagonize the activity of IL1 by inducing the expression and release of this cytokine. Recombinant soluble IL1RII is thus a potent antagonist of IL1 action, and serves as a potential therapeutic target.

References

  1. McMahan CJ. et al., 1991, EMBO J. 10: 2821-32.
  2. Liu C. et al., 1996, J Biol Chem. 271: 20965-72.
  3. Rauschmayr T. et al., 1997, Proc Natl Acad Sci. 94: 5814-19.
  4. Neumann D. et al., 2000, J Immunol. 165: 3350-7.
  5. Colotta F. et al., 1993, Science. 261: 472-5.
 

All IL-1 Proteins

Product nameProduct name
IL18 Protein (Native)IL-1 alpha / IL1A / IL1F1 Protein
IL18BPa ProteinMouse IL1R1 / CD121a Protein (His Tag)
IL18BPa Protein (His Tag)Cynomolgus IL-1 beta / IL1B Protein (Native)
IL1F5 / IL36RN Protein (Native)IL36B / IL1F8 Protein (Native)
IL1R2 / CD121b ProteinIL1F6 / IL36A Protein (Native)
IL1RL1 / DER4 ProteinMouse IL-1R8 / IL1RAPL1 Protein
IL1RL1 / DER4 ProteinCanine IL-1 beta / IL1B Protein (Native)
IL1R9 ProteinIL36G / IL1F9 Protein (Native)
IL1RA / IL1F3 ProteinMouse IL1F8 / IL36b Protein Native
IL1RA / IL1F3 Protein (Native)IL37 / IL1F7 / IL-1H4 Protein Native
IL-1 alpha / IL1A / IL1F1 ProteinMouse IL1R1 / CD121a Protein
IL33 / Interleukin-33 / NF-HEV Protein (Native)Canine IL33 / Interleukin-33 / NF-HEV Protein (Native)
Mouse IL-18R1 ProteinIL36B / IL1F8 Protein (His Tag)
IL-1R8 ProteinIL1F6 / IL36A Protein (His Tag)
Mouse SIGIRR ProteinRat IL18R1 Protein
IL1R8 Protein (His Tag)Rat IL1R2 / IL1RB / CD121b Protein (His Tag)
IL1R3 ProteinIL36G / IL1F9 (aa 18-169) Protein (His Tag)
IL1R1 / CD121a ProteinIL36G / IL1F9 (aa 18-169) Protein
IL1R1 / CD121a Protein (His Tag)IL1F6 / IL36 (aa 6-158) Protein
IL-1 beta / IL1B Protein (Native)Mouse IL-18 Protein (Native)
Mouse IL18BP Protein (His Tag)Mouse IL1R2 / CD121b Protein
IL18RAP / IL1R7 ProteinMouse IL1R2 / CD121b Protein (His Tag)
IL18R1 / CD218a Protein (His Tag)Rat IL1RN / IL1RA Protein
IL1R3 / IL1RAP Protein (His Tag)Cynomolgus IL18RAP Protein
IL18R1 / CD218a ProteinCynomolgus IL18RAP Protein (His Tag)
IL1RL1 / ST2 Protein (His Tag)Rat IL1R2 / IL1RB / CD121b Protein
IL1R2 / IL1RB / CD121b Protein (His Tag)Cynomolgus IL1R2 / IL1RB Protein
Mouse IL18R1 / CD218a Protein (His Tag)Mouse IL18 / IL-18 Protein
IL18RAP / IL1R7 Protein (His Tag)IL18 / Interleukin 18 / IGIF Protein (GST Tag)
Mouse IL-1 alpha / IL1A / IL1F1 Protein (Native)IL1R1 / CD121a Protein
Mouse IL1F5 / IL1RP3 Protein (Native)IL1R2 / IL1RB / CD121b Protein
IL1R9 / IL1RAPL2 / IL1 Receptor 9 Protein (His Tag)SIGIRR / TIR8 Protein
Rat IL-1 beta / IL1B ( pro form ) Protein (His Tag)Cynomolgus IL1R1 Protein
SIGIRR / TIR8 Protein (His Tag)Cynomolgus IL1R1 Protein (His Tag)
Cynomolgus IL-18 / IL-1F4 Protein (His Tag)Canine IL18R1 Protein
Mouse IL-1F6 / IL-1 epsilon Protein (Native)Canine IL1R2 / IL1RB Protein
IL-1 beta / IL1B (pro form) Protein (His Tag)Rat IL18R1 Protein (His Tag)
Rat IL1R1 / CD121a Protein (His Tag)Mouse IL36G / IL1F9 Protein (His Tag)
Mouse IL-1 beta / IL1B Protein (Native)Cynomolgus IL18R1 Protein
Rat IL1R1 / CD121a ProteinRabbit IL-1 beta / IL1B Protein
IL1RL1 / ST2 (isoform A) Protein (His Tag)Cynomolgus IL18R1 Protein (His Tag)
Rat IL-1 beta / IL1B (mature form) Protein (Native) 

All IL-1 Antibodies

Product nameProduct name
IL1RL1 / ST2 Antibody (Mouse Monoclonal Antibody)IL-18 Antibody (Antigen Affinity Purified)
IL1RL1 / ST2 AntibodySIGIRR / TIR8 Antibody
IL33 / Interleukin-33 / NF-HEV Antibody (Mouse Monoclonal Antibody)SIGIRR / TIR8 Antibody (Antigen Affinity Purified)
IL33 / Interleukin-33 / NF-HEV AntibodyIL18 / Interleukin-18 Antibody
IL18BP / IL18BPa Antibody (Mouse Monoclonal Antibody)IL-1RA Antibody
IL18BP / IL18BPa AntibodyIL-1R8 / IL1RAPL1 Antibody
IL18BP / IL18BPa AntibodyIL-1R2 / CD121b Antibody
IL18BP / IL-18BP AntibodyIL-1R9 / IL1RAPL2 Antibody (Antigen Affinity Purified)
IL18BP / IL18BPa Antibody (Antigen Affinity Purified)IL-1 beta / IL1B Antibody (Antigen Affinity Purified)
IL1R1 / CD121a AntibodyIL-1F6 Antibody (Antigen Affinity Purified)
IL1R1 / CD121a Antibody (Antigen Affinity Purified)IL-1R1 / CD121a Antibody (Antigen Affinity Purified)
IL1RL1 / ST2 Antibody (Antigen Affinity Purified)IL-1 beta / IL1B Antibody (Antigen Affinity Purified)
IL18BP / IL-18BP Antibody (Antigen Affinity Purified)IL-33 Antibody
IL1R1 / CD121a Antibody (Mouse Monoclonal Antibody)IL-1RA Antibody (FITC)
IL18R1 / CD218a AntibodyIL-1 alpha / IL-1F1 / IL1A Antibody (Antigen Affinity Purified)
IL18R1 / CD218a Antibody (Antigen Affinity Purified)IL18BP / IL18BPa Antibody
IL33 / Interleukin-33 / NF-HEV AntibodyIL1F6 / IL36A Antibody
IL33 / Interleukin-33 / NF-HEV Antibody (Antigen Affinity Purified)IL-1 alpha / IL-1F1 / IL1A Antibody
IL1R3 / IL1RAP AntibodyIL-1R1 / CD121a Antibody
IL1R2 / IL1RB / CD121b AntibodyIL-33 Antibody
IL1R2 / IL1RB / CD121b Antibody (Antigen Affinity Purified)IL-33 Antibody
IL-1 beta / IL1B / IL1F2 AntibodyIL-33 Antibody (FITC)
IL-1 beta / IL1B / IL1F2 Antibody (Antigen Affinity Purified)IL1F6 / IL36A Antibody
IL1R1 / CD121a AntibodyIL-18 Antibody
IL18R1 / IL1RRP / CD218a AntibodyIL37 / IL1F7 / IL-1H4 Antibody
IL18R1 / IL1RRP / CD218a Antibody (Antigen Affinity Purified)IL-1F5 Antibody
IL18R1 / CD218a AntibodyIL-1RAcP / IL-1R3 Antibody (FITC)
IL18BP / IL-18BP AntibodyIL-1RAcP / IL-1R3 Antibody (PE)
IL18BP / IL-18BP AntibodyIL-1RA Antibody (PE)
IL1R2 / IL1RB / CD121b AntibodyIL-33 Antibody (PE)
IL1R2 / IL1RB / CD121b AntibodyIL-33 Antibody (FITC)
IL1R2 / IL1RB / CD121b AntibodySIGIRR / TIR8 Antibody
IL18R1 / CD218a AntibodyIL1R1 / CD121a Antibody
IL1RA / IL1F3 AntibodyIL1R1 / CD121a Antibody
IL-1 beta / IL1B / IL1F2 AntibodyIL-1 beta / IL1B Antibody
IL18R1 AntibodyIL-1 beta / IL1B Antibody
IL1RL1 AntibodyIL-1R1 / CD121a Antibody
IL1RL1 AntibodyIL-1R1 / CD121a Antibody
IL-1RAcP / IL-1R3 Antibody (Antigen Affinity Purified)IL-1RA Antibody (Antigen Affinity Purified)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"