IL18RAP Protein (IL-18RB, CD218b Protein)

Interleukin 18 Receptor Accessory Protein (IL-1 Receptor 7, Cluster of Differentiation 218b)

IL18RAP Products

IL18RAP Protein, Recombinant

Molecule	Species	Description	Cat. No
IL18RAP/IL-1R7/CD218b	Human	IL18RAP/IL-1R7/CD218b/Fc Protein, Recombinant	10176-H02H
IL18RAP/IL-1R7/CD218b	Human	IL18RAP/IL-1R7/CD218b Protein, Recombinant	10176-H08H

IL18RAP cDNA Clone

Molecule	Species	Description	Cat. No
IL18RAP/IL-1R7/CD218b	Human	Homo sapiens IL18RAP/IL-1R7/CD218b cDNA Clone(NM_003853.2)	HG10176-M
IL18RAP/IL-1R7/CD218b	Mouse	Mouse IL18RAP/IL-1R7/CD218b cDNA Clone / ORF Clone	MG50845-G
IL18RAP/IL-1R7/CD218b	Cynomolgus	Cynomolgus monkey IL18RAP cDNA Clone / ORF Clone	KG90122-G

IL18RAP Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family>>IL18RAP/IL-1R7/CD218b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL18RAP/IL-1R7/CD218b

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>IL18RAP/IL-1R7/CD218b

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL18RAP/IL-1R7/CD218b

IL18RAP Alternative Names

ACPL, CD218b, CDw218b, IL18RB, MGC120589, MGC120590 [Homo sapiens]

AcPL accessory protein-like), CD218 antigen-like family member B, IL-18 receptor accessory protein, IL-18R-beta, IL-18RAcP [Mus musculus]

IL18RAP Background

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.

IL18RAP Related Studies

1. Zhernakova A, et al.. (2008) Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet. 82(5): 1202-10.
2. Grisoni ML, et al.. (2009) Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 10: 44.
3. Koskinen LL, et al.. (2009) Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet. 18(6): 1148-55.