All IL18RAP reagents are produced in house and quality controlled, including 9 IL18RAP Antibody, 1 IL18RAP ELISA, 36 IL18RAP Gene, 5 IL18RAP Lysate, 5 IL18RAP Protein, 2 IL18RAP qPCR. All IL18RAP reagents are ready to use.
Recombinant IL18RAP proteins are expressed by Baculovirus-Insect cells, HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc.
IL18RAPantibodies are validated with different applications, which are ELISA, WB, ELISA(Det), ELISA(Cap), IHC-P.
IL18RAPcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL18RAP of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL18RAPELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.