All IL18R1 reagents are produced in house and quality controlled, including 16 IL18R1 Antibody, 4 IL18R1 ELISA, 45 IL18R1 Gene, 10 IL18R1 Lysate, 10 IL18R1 Protein, 3 IL18R1 qPCR. All IL18R1 reagents are ready to use.
Recombinant IL18R1 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc & His, C-His, C-human IgG1-Fc.
IL18R1antibodies are validated with different applications, which are ELISA, ELISA(Det), FCM, ELISA(Cap), WB.
IL18R1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL18R1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL18R1ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.