IL18R1 Protein & Antibody (IL-1Rrp, CD218a)

Interleukin-18 Receptor 1 (IL-1 Receptor related protein, Cluster of Differentiation 218a)

IL18R1 Products

IL18R1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL18R1/IL-1Rrp/CD218a	Human	IL18R1/IL-1Rrp/CD218a Protein, Recombinant	11102-H03H
IL18R1/IL-1Rrp/CD218a	Human	IL18R1/IL-1Rrp/CD218a Protein, Recombinant	11102-H08H
IL18R1/IL-1Rrp	Mouse	IL18R1/IL-1Rrp/Fc Protein, Recombinant	50094-M03H
IL18R1/IL-1Rrp	Mouse	IL18R1/IL-1Rrp Protein, Recombinant	50094-M08H
IL18R1/IL-1Rrp	Rat	IL18R1 Protein, Recombinant	80191-R02H

11102-H03H: Measured by its ability to bind cynomolgus IL-18 in a functional Elisa.

IL18R1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL18R1/IL-1Rrp/CD218a	WB, ELISA	IL18R1/IL-1Rrp/CD218a Antibody, Mouse Mab	11102-MM08
Human IL18R1/IL-1Rrp/CD218a	WB, ELISA	IL18R1/IL-1Rrp/CD218a Antibody, Rabbit MAb	11102-R011
Human IL18R1/IL-1Rrp/CD218a	WB, ELISA	Rabbit Polyclonal Antibody	11102-RP01
Human IL18R1/IL-1Rrp/CD218a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11102-RP02
Mouse IL18R1/IL-1Rrp	WB, ELISA	IL18R1/IL-1Rrp/CD218a Antibody, Rabbit PAb	50094-RP01
Mouse IL18R1/IL-1Rrp	WB, ELISA	IL18R1/IL-1Rrp/CD218a Antibody, Rabbit PAb (Antigen Affinity Purified)	50094-RP02
Mouse IL18R1/IL-1Rrp	WB, ELISA	IL18R1 Antibody	50094-R013

IL18R1 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL18R1/IL-1Rrp/CD218a	ELISA	IL18R1/IL-1Rrp/CD218a ELISA Kit	SEK11102
Mouse IL18R1/IL-1Rrp/CD218a	ELISA	IL18R1 ELISA Pair Set, Mouse ELISA Pair Set	SEK50094

IL18R1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL18R1/IL-1Rrp/CD218a	Human	Homo sapiens IL18R1/IL-1Rrp/CD218a cDNA Clone	HG11102-M
IL18R1/IL-1Rrp	Mouse	Mus musculus IL18R1/IL-1Rrp cDNA Clone	MG50094-M
IL18R1/IL-1Rrp	Canine	Canine IL18R1 Gene cDNA Clone / ORF Clone	DG70081-G
IL18R1/IL-1Rrp	Rat	Rat IL18R1/IL-1Rrp cDNA Clone	RG80191-G
IL18R1/IL-1Rrp	Cynomolgus	Cynomolgus monkey IL18R1 cDNA Clone / ORF Clone	CG90121-G

IL18R1 Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL18R1/IL-1Rrp/CD218a

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL18R1/IL-1Rrp/CD218a

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL18R1/IL-1Rrp/CD218a

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>IL18R1/IL-1Rrp/CD218a

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL18R1/IL-1Rrp/CD218a

IL18R1 Alternative Names

IL18R1, IL-1Rrp, CD218a, CDw218a, IL18RA, IL1RRP [Homo sapiens]

Il18r1, Il1rrp, Il18ralpha [Mus musculus]

IL18R1 Background

Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

IL18R1 Related Studies

Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.

IL-1 Family & Receptor