IL18R1 Matched ELISA Antibody Pair Set,Mouse

Cat: SEK50094
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IL18R1 Matched ELISA Antibody Pair Set,Mouse General Information
Product name
IL18R1 Matched ELISA Antibody Pair Set,Mouse
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Mouse IL18R1
Assay range
15.63-1000
Materials provided
1. Capture Antibody 0.5 mg/mL of rabbit anti-mouse IL18R1 monoclonal antibody. Dilute to a working concentration of 1.0 μg/mL in CBS before coating. (Catalog: # 50094-R006)
2. Detection Antibody 0.5 mg/mL rabbit anti-mouse IL18R1 monoclonal antibody conjugated to horseradish-peroxidase (HRP). Dilute to working concentration of 0.25 μg/mL in detection antibody dilution buffer before use. (Catalog: # 50094-R032)
3. Standard Each vial contains 35 ng of recombinant mouse IL18R1. Reconstitute standard powder with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 1000 pg/mL is recommended.
Product overview
This IL18R1 Matched ELISA Antibody Pair Set,Mouse is a solid phase sandwich ELISA for quantitative determination of Mouse IL18R1 . It contains Mouse IL18R1 capture antibody, Mouse IL18R1 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Mouse IL18R1 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Protect it from prolonged exposure to light. Aliquot and store at -20℃ to -80℃ and for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
IL18R1 Matched ELISA Antibody Pair Set,Mouse Images
Mouse IL18R1 ELISA Pair Set Standard Curve 13982
IL18R1 Matched ELISA Antibody Pair Set,Mouse Alternative Names
Il18ralpha Matched ELISA Antibody Pair Set, Mouse;Il1rrp Matched ELISA Antibody Pair Set, Mouse
IL18R1 Background Information

Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

Full Name
interleukin 18 receptor 1
References
  • Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
  • Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
  • Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.
  • Product Description Assay Range (pg/ml) Sample Type Catalog# (PDF)
    IL18R1 ELISA Kit, Mouse Lysate KIT50094
    IL18R1 ELISA Kit, Human Serum KIT11102
    IL18R1 Matched ELISA Antibody Pair Set,Human 7.8 pg/ml SEK11102
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