Anti-IL18R1 Antibody

Cat: 11102-RP02
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Anti-IL18R1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL18R1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL18R1
Immunogen
Recombinant Human IL18R1 protein (Catalog#11102-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL18R1 / CD218a (rh IL18R1; Catalog#11102-H08H; NP_003846.1; Met 1-Arg 329). IL18R1 specific IgG was purified by human IL18R1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL18R1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL18R1 Antibody Alternative Names
Anti-CD218a Antibody;Anti-CDw218a Antibody;Anti-IL-1Rrp Antibody;Anti-IL18RA Antibody;Anti-IL1RRP Antibody
IL18R1 Background Information

Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

Full Name
interleukin 18 receptor 1
References
  • Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
  • Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
  • Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL18R1 Antibody Rabbit Polyclonal WB,ELISA 90121-T48
    Anti-IL18R1 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 50094-R032
    Anti-IL18R1 Antibody Rabbit Polyclonal ELISA 50094-RP02
    Anti-IL18R1 Antibody Rabbit Polyclonal ELISA 50094-T16
    Anti-IL18R1 Antibody Rabbit Monoclonal ELISA(Cap) 50094-R006
    Anti-IL18R1 Antibody Rabbit Monoclonal ELISA 50094-R013
    Anti-IL18R1 Antibody Rabbit Polyclonal ELISA 50094-RP01
    Anti-IL18R1 Antibody Mouse Monoclonal ELISA(Det) 11102-MM05
    Anti-IL18R1 Antibody (FITC) Mouse Monoclonal FCM 11102-MM17-F
    Anti-IL18R1 Antibody Mouse Monoclonal FCM 11102-MM17
    Anti-IL18R1 Antibody Mouse Monoclonal ELISA 11102-MM08
    Anti-IL18R1 Antibody (APC) Mouse Monoclonal FCM 11102-MM17-A
    Anti-IL18R1 Antibody (PE) Mouse Monoclonal FCM 11102-MM17-P
    Anti-IL18R1 Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 11102-R011
    Anti-IL18R1 Antibody Rabbit Polyclonal ELISA 11102-RP01
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