Anti-IL-18 Antibody

Cat: 10119-MM15

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Anti-IL-18 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IL-18 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human IL-18
Recombinant Human IL18 / IL-18 / Interleukin 18 Protein (Catalog#10119-H09E)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL18 / IL-18 / Interleukin 18 (rh IL18 / IL-18 / Interleukin 18; Catalog#10119-H09E; Q14116; Met1-Asp193). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #15
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-18 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-18 Antibody Alternative Names
Anti-IGIF Antibody;Anti-IL-18 Antibody;Anti-IL-1g Antibody;Anti-IL1F4 Antibody;Anti-Interleukin 18 Antibody
IL-18 Background Information

Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 18
  • Dinarello CA. (1999) IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 103: 11-24.
  • Takeda K, et al.. (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8(3): 383-90.
  • Gracie JA, et al.. (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 104(10): 1393-401.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-18 Antibody Mouse Monoclonal ELISA 90011-MM02
    Anti-IL-18 Antibody Rabbit Polyclonal WB,IP 90011-RP02
    Anti-IL-18 Antibody Mouse Monoclonal ELISA 90011-MM17
    Anti-IL-18 Antibody Rabbit Polyclonal ELISA 90011-RP01
    Anti-IL-18 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 50073-R167
    Anti-IL-18 Antibody Rabbit Polyclonal WB,ELISA 50073-T48
    Anti-IL-18 Antibody Rabbit Monoclonal ELISA(Cap) 50073-R169
    Anti-IL-18 Antibody Rabbit Polyclonal ELISA 50073-T16
    Anti-IL-18 Antibody Rabbit Polyclonal ELISA 50073-RP01
    Anti-IL-18 Antibody Rabbit Polyclonal ELISA 10119-T16
    Anti-IL-18 Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 10119-R011
    Anti-IL-18 Antibody Rabbit Polyclonal WB,ELISA,IP 10119-T52
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