IL17RC Protein (Cytokine)

Interleukin 17 receptor C Protein Datasheet

IL17RC Protein Product Information

• Synonym: UNQ6118/PRO20040/PRO38901, FLJ95963, FLJ96005, IL17-RL, IL17RL, MGC10763
• Protein Construction: A DNA sequence encoding the extracellular domain of human IL17RC isoform 3 (NP_116121.2) (Met 1- Ala 454) was fused with the Fc region of human IgG1 at the C-terminus.
• Source: Human
• Expression Host: Human Cells

IL17RC Protein QC Testing

• Purity: >95 % as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Leu 21
• Molecular Mass: The secreted recombinant human IL17RC/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 675 amino acids and has a predicted molecular mass of 75.3 kDa. The apparent molecular mass of rh IL17RC/Fc monomer is approximately 100-120 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Formulation: Lyophilized from sterile PBS, pH7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: IL17RC protein

IL17RC Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL17RC Protein Description

Interleukin-17 receptor C (IL-17RC) is a single-pass transmembrane protein that shares similarity with the IL-17R. IL-17RC functions as a receptor for both IL-17A and IL-17F, both of which are considered as factors contributing to the progression of inflammatory and autoimmune diseases. IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor complex, comprised of the IL-17RA and IL-17RC subunits. Soluble version of IL-17RC should be an effective antagonist of IL-17A and IL-17F mediated inflammatory diseases. IL-17RC and IL-17RA have been found to be overexpressed in rheumatoid arthritis (RA) peripheral whole blood and their expression was detected locally in RA synovium. IL-17RC protein expression was significantly higher in androgen-independent prostate cancers than in androgen-dependent ones. This protein is differentially expressed in prostatic cells and cancer tissues and may play a negative or positive role in the initiation and progression of prostate cancer.

References

1. Allen W. et al., 2010, Semin Immunopathol. 32 (1): 33-42.
2. You ZB. et al., 2007, Neoplasia. 9 (6): 464-70.
3. Zrioual S. et al., 2008, J Immunol. 180 (1):655-63.
4. Kuestner RE. et al., 2010, J Immunol. 179 (8): 5462-73.