IL17RC Protein & Antibody

Interleukin 17 receptor C

IL17RC Products

IL17RC Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
IL17RC	Human	IL17RC Protein, Recombinant	11747-H02H
IL17RC	Human	IL17RC (aa 1-454) Protein, Recombinant	11747-H08B

IL17RC Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat No
Human IL17RC	ELISA	IL17RC Antibody	11747-RP01
Human IL17RC	ELISA	IL17RC Antibody (Antigen Affinity Purified)	11747-RP02
Human IL17RC	ELISA	IL17RC Antibody	11747-MM02

IL17RC Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-17 Family & IL-17 Receptor Family>> IL-17RC

IL17RC Alternative Names

UNQ6118, PRO20040, PRO38901, FLJ95963, FLJ96005, IL17-RL, IL17RL, MGC10763[Homo sapiens]

1110025H02Rik, IL-17RC, IL17-RC, IL17-RL, Il17rl[Mus musculus]

IL17RC Background

Interleukin-17 receptor C (IL-17RC) is a single-pass transmembrane protein that shares similarity with the IL-17R. IL-17RC functions as a receptor for both IL-17A and IL-17F, both of which are considered as factors contributing to the progression of inflammatory and autoimmune diseases. IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor complex, comprised of the IL-17RA and IL-17RC subunits. Soluble version of IL-17RC should be an effective antagonist of IL-17A and IL-17F mediated inflammatory diseases. IL-17RC and IL-17RA have been found to be overexpressed in rheumatoid arthritis (RA) peripheral whole blood and their expression was detected locally in RA synovium. IL-17RC protein expression was significantly higher in androgen-independent prostate cancers than in androgen-dependent ones. This protein is differentially expressed in prostatic cells and cancer tissues and may play a negative or positive role in the initiation and progression of prostate cancer.

IL17RC Related Studies

Allen W, et al. (2010) IL-17RC: A partner in IL-17 signaling and beyond. Semin Immunopathol. 32(1): 33-42.
You ZB, et al. (2007) Differential Expression of IL-17RC Isoforms in Androgen-Dependent and Androgen-Independent Prostate Cancers1. Neoplasia. 9(6): 464-70.
Zrioual S, et al. (2008) IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J Immunol. 180(1): 655-63.
Kuestner RE, et al. (2010) Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F. J Immunol.179(8): 5462-73.