IL17RC Antibody (Antigen Affinity Purified) (Cytokine)

IL17RC Antibody ( Antigen Affinity Purified ) Datasheet

IL17RC Antibody Product Information

• Immunogen: Recombinant Human IL17RC protein (Catalog#11747-H08B)
• Antibody Type: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: Produced in rabbits immunized with purified, recombinant Human IL17RC (rh IL17RC; Catalog#11747-H08B; NP_116121.2; Met 1-Ala 454). IL17RC specific IgG was purified by Human IL17RC affinity chromatography.

IL17RC Antibody Usage Guide

• Specificity: Human IL17RC
• Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL17RC. The detection limit for Human IL17RC is approximately 0.00975 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

IL17RC Antibody Background

Interleukin-17 receptor C (IL-17RC) is a single-pass transmembrane protein that shares similarity with the IL-17R. IL-17RC functions as a receptor for both IL-17A and IL-17F, both of which are considered as factors contributing to the progression of inflammatory and autoimmune diseases. IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor complex, comprised of the IL-17RA and IL-17RC subunits. Soluble version of IL-17RC should be an effective antagonist of IL-17A and IL-17F mediated inflammatory diseases. IL-17RC and IL-17RA have been found to be overexpressed in rheumatoid arthritis (RA) peripheral whole blood and their expression was detected locally in RA synovium. IL-17RC protein expression was significantly higher in androgen-independent prostate cancers than in androgen-dependent ones. This protein is differentially expressed in prostatic cells and cancer tissues and may play a negative or positive role in the initiation and progression of prostate cancer.

References

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4. Kuestner RE. et al., 2010, J Immunol. 179 (8): 5462-73.