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Cynomolgus monkey IL17RA Gene cDNA Clone (full-length ORF Clone)

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IL17RAcDNA Clone Product Information
Gene Bank Ref.ID:unsubmitted
cDNA Size:2598
cDNA Description:ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) interleukin 17 receptor A DNA.
Gene Synonym:IL17RA
Species:Cynomolgus
Vector:pGEM-T Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with XM_001093896.2 [ Macaca mulatta (Rhesus monkey) ]: 1069 G/A, 1892 T/C, 2207 A/C resulting in the amino acid Asp substitution by Asn, Val substitution by Ala, His substitution by Pro and 468 G/A,1515 C/T,1650 C/G,2169 C/T,2223 A/G,2424 G/A not causing the amino acid variation. Please check the sequence information before order.
Shipping Carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Cynomolgus monkey IL17RA Gene cDNA Clone (full-length ORF Clone) on other vectors
IL-17 Family & Receptor Related Products
Product nameProduct name
Human IL17RD Protein (His Tag)Human IL17 / IL17A ProteinHuman IL17 / IL17A ProteinRat IL17F / IL-17F Protein (His Tag)Canine IL17 / IL17A ProteinHuman IL-17F / Interleukin-17F Protein (His Tag)Human IL-17F / IL17F ProteinRat IL17RA / IL17R Protein (Fc Tag)Rat IL17RA / IL17R Protein (His Tag)Rat Interleukin 25 / IL25 / IL17E Protein (Fc Tag)Canine IL17RD Protein (His Tag)Human IL17BR / IL17RB / IL-17 Receptor B Protein (Fc Tag)Human IL17BR / IL17RB / IL-17 Receptor B Protein (His Tag)Human IL17RB / IL-17 Receptor B Protein (Flag Tag)Mouse IL17F / IL-17F Protein (His Tag)Mouse IL17F / IL-17F ProteinMouse IL25 Protein (His Tag)Human p38 alpha / MAPK14 Protein (His Tag)Cynomolgus IL17RA / IL17R Protein (Fc Tag)Mouse IL17B / IL-17B Protein (Fc Tag)Human p38 alpha / MAPK14 Protein (Activated in vitro, His Tag)Human p38 delta / MAPK13 Protein (Activated in vitro, GST Tag)Human p38 delta / MAPK13 Protein (GST Tag)Human IL17RC Protein (Fc Tag)Human IL17RC Protein (aa 1-454, His Tag)Marmoset IL17 / IL17A ProteinMouse IL17RA / IL17R / CD217 Protein (Fc Tag)Mouse IL17RA / IL17R / CD217 Protein (His Tag)Mouse IL17 / IL17A ProteinMouse IL17BR / IL17RB / IL-17 Receptor B Protein (Fc Tag)Mouse IL17BR / IL17RB / IL-17 Receptor B Protein (His Tag)Human ERK2 / MAPK1 / MAPK2 Protein (GST Tag)Human IKB alpha / NFKBIA Protein (His Tag)Human IL17 / IL17A Protein (His Tag)Human RELA / Transcription factor p65 / NFkB p65 Protein (aa 1-306, GST Tag)Mouse ERK2 / MAPK1 / MAPK2 Protein (His & GST Tag)Mouse ERK2 / MAPK1 / MAPK2 ProteinHuman p38 alpha / MAPK14 Protein (His Tag)Human p38 alpha / MAPK14 Protein (His Tag)Human IL17RA / CD217 Protein (His & Fc Tag)Human IL17RA / CD217 Protein (His Tag)Human IL25 Protein (Fc Tag)
Background

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

References
  • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
  • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
  • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
  • Catalog:CG90127-G
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    Price:$145.00      [How to order]
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