Text Size:AAA

Cynomolgus IL17RA / IL17R Protein (Fc Tag)

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
IL17RAProtein Product Information
Synonym:IL17RA
Protein Construction:A DNA sequence encoding the cynomolgus IL17RA (Met1-Trp320) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Species:Cynomolgus
Expressed Host:Human Cells
Form & Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
IL17RAProtein QC Testing
Purity:> 90 % as determined by SDS-PAGE
Bio-Activity:Immobilized human IL17A (Cat:12047-HNAS) at 10 μg/ml (100 μl/well) can bind Cynomolgus IL17RA-Fc, The EC50 of Cynomolgus IL17RA-Fc is 0.19-0.43 μg/ml.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Leu 33
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Molecule Mass:The recombinant cynomolgus IL17RA is a disulfide-linked homodimer. The reduced monomer comprises 529 amino acids and has a calculated molecular mass of 60.3 KDa.The apparent molecular mass of the protein is approximately 75-98 KDa respectively in SDS-PAGE.
IL17RAProtein Usage Guide
Storage:Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
90127-C02H
Background

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

References
  • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
  • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
  • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
  • Cynomolgus IL17RA / IL17R Protein (Fc Tag) on other vectors Cynomolgus IL17RA / IL17R Protein (Fc Tag) on other vectors
    IL-17 Family & Receptor Related Products
    Product nameProduct name
    Human IL17RD Protein (His Tag)Human IL17 / IL17A ProteinHuman IL17 / IL17A ProteinRat IL17F / IL-17F Protein (His Tag)Canine IL17 / IL17A ProteinHuman IL-17F / Interleukin-17F Protein (His Tag)Human IL-17F / IL17F ProteinRat IL17RA / IL17R Protein (Fc Tag)Rat IL17RA / IL17R Protein (His Tag)Rat Interleukin 25 / IL25 / IL17E Protein (Fc Tag)Canine IL17RD Protein (His Tag)Human IL17BR / IL17RB / IL-17 Receptor B Protein (Fc Tag)Human IL17BR / IL17RB / IL-17 Receptor B Protein (His Tag)Human IL17RB / IL-17 Receptor B Protein (Flag Tag)Mouse IL17F / IL-17F Protein (His Tag)Mouse IL17F / IL-17F ProteinMouse IL25 Protein (His Tag)Human p38 alpha / MAPK14 Protein (His Tag)Cynomolgus IL17RA / IL17R Protein (Fc Tag)Mouse IL17B / IL-17B Protein (Fc Tag)Human p38 alpha / MAPK14 Protein (Activated in vitro, His Tag)Human p38 delta / MAPK13 Protein (Activated in vitro, GST Tag)Human p38 delta / MAPK13 Protein (GST Tag)Human IL17RC Protein (Fc Tag)Human IL17RC Protein (aa 1-454, His Tag)Marmoset IL17 / IL17A ProteinMouse IL17RA / IL17R / CD217 Protein (Fc Tag)Mouse IL17RA / IL17R / CD217 Protein (His Tag)Mouse IL17 / IL17A ProteinMouse IL17BR / IL17RB / IL-17 Receptor B Protein (His Tag)Human ERK2 / MAPK1 / MAPK2 Protein (GST Tag)Human IKB alpha / NFKBIA Protein (His Tag)Human IL17 / IL17A Protein (His Tag)Human RELA / Transcription factor p65 / NFkB p65 Protein (aa 1-306, GST Tag)Mouse ERK2 / MAPK1 / MAPK2 Protein (His & GST Tag)Mouse ERK2 / MAPK1 / MAPK2 ProteinHuman p38 alpha / MAPK14 Protein (His Tag)Human p38 alpha / MAPK14 Protein (His Tag)Human IL17RA / CD217 Protein (His & Fc Tag)Human IL17RA / CD217 Protein (His Tag)Human IL25 Protein (Fc Tag)
    Catalog:90127-C02H-100
    List Price: $178.00  (Save $0.00)
    Price:$178.00      [How to order]
    Availabilityon Sale
    Images
    • Cynomolgus IL17RA / IL17R Protein (Fc Tag) SDS-PAGE
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"