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IL17A/IL-17A/IL17  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Baculovirus-Insect Cells  
  • Slide 1
12047-H07B-50
12047-H07B-5
12047-H07B-20
12047-H07B-100
50 µg 
5 µg 
20 µg 
100 µg 
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Expression host: E. coli  
  • Slide 1
12047-HNAE-5
12047-HNAE-20
12047-HNAE-100
5 µg 
20 µg 
100 µg 
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Expression host: Yeast  
  • Slide 1
12047-H07Y-50
12047-H07Y-100
50 µg 
100 µg 
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Expression host: CHO Stable Cells  
  • Slide 1
12047-HNAS-500
12047-HNAS-5
12047-HNAS-20
12047-HNAS-100
12047-HNAS-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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Description: Active  
Expression host: E. coli  
  • Slide 1
51065-MNAE-50
51065-MNAE-20
50 µg 
20 µg 
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Expression host: E. coli  
  • Slide 1
70102-DNAE-50
70102-DNAE-100
50 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
  • Slide 1
90306-KNAB-20
90306-KNAB-100
20 µg 
100 µg 
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Description:   
Expression host: Baculovirus-Insect Cells  
  • Slide 1
65006-T07B-5
65006-T07B-20
65006-T07B-100
5 µg 
20 µg 
100 µg 
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Expression host: E. coli  
  • Slide 1
90287-CNAE-50
90287-CNAE-100
50 µg 
100 µg 
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IL17A/IL-17A/IL17 Related Area

IL17A/IL-17A/IL17 Related Pathways

    IL17A/IL-17A/IL17 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    IL17A/IL-17A/IL17 Summary & Protein Information

    IL17A/IL-17A/IL17 Background

    Gene Summary: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis
    General information above from NCBI
    Subunit structure: Homodimer.
    Subcellular location: Secreted.
    Tissue specificity: Restricted to activated memory T-cells.
    Post-translational: Found both in glycosylated and nonglycosylated forms.
    Sequence similarity: Belongs to the IL-17 family.
    General information above from UniProt

    IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

    IL17A/IL-17A/IL17 Alternative Name

    IL17,CTLA8,IL-17,IL-17A, [homo-sapiens]
    CTLA8,CTLA-8,cytotoxic T-lymphocyte-associated antigen 8,cytotoxic T-lymphocyte-associated protein 8,cytotoxic T-lymphocyte-associated serine esterase 8,IL17,IL-17,IL-17A,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8),interleukin-17A, [human]
    Ctla8,Ctla-8,cytotoxic T-lymphocyte-associated antigen 8. interleukin-17A,Il17,IL-17,IL-17A, [mouse]
    Il17,Ctla8,IL-17,Ctla-8,IL-17A, [mus-musculus]

    IL17A/IL-17A/IL17 Related Studies

  • Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
  • Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
  • Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
  • Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.
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