IL13RA2 Protein & Antibody (CD213a2)

Interleukin 13 Receptor, alpha 2 (Cluster of Differentiation 213a2)

IL13RA2 Products

IL13RA2 Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-13RA2/CD213a2	Human	IL-13RA2/CD213a2/Fc Protein, Recombinant	10350-H03H
IL-13RA2/CD213a2	Mouse	IL-13RA2/CD213a2/Fc Protein, Recombinant	50061-M03H
IL-13RA2/CD213a2	Mouse	IL-13RA2/CD213a2 Protein, Recombinant	50061-M08H

  10350-H03H: Immobilized recombinant human IL13RA2 at 8 μg/mL (100μl/well) can bind IL13 with a linear range of 0.25 - 8.0 ng/ml. Measured by its binding ability in a functional ELISA.

  50061-M03H: Immobilized human IL13 at 20 μg/ml ( 100 μl/well ) can bind mouse IL13RA2 with a linear ranger of 0.5 - 2 μg/ml. Measured by its binding ability in a functional ELISA.

  50061-M08H:  Measured by its ability to compete with mouse  IL13RA2 for binding to immobilized human IL13 in a functional ELISA assay.

IL13RA2 Antibody

Molecule	Application	Description	Cat. No
Mouse IL-13RA2/CD213a2	WB, ELISA	IL13RA2/CD213a2 Antibody, Rabbit MAb	50061-R015
Mouse IL-13RA2/CD213a2	WB, ELISA	Rabbit Polyclonal Antibody	50061-RP01
Mouse IL-13RA2/CD213a2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50061-RP02

IL13RA2 cDNA Clone

Molecule	Species	Description	Cat. No
IL-13RA2/CD213a2	Human	Homo sapiens IL-13RA2/CD213a2 cDNA Clone(NM_000640.2)	HG10350-M
IL-13RA2/CD213a2	Mouse	Mus musculus IL13RA2/CD213a2 cDNA Clone	MG50061-M
IL-13RA2/CD213a2	Rat	Rat IL13RA2/CD213a2 cDNA Clone	RG80204-G

IL13RA2 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-13RA2/CD213a2

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-13RA2/CD213a2

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL-13RA2/CD213a2

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL-13RA2/CD213a2

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL-13RA2/CD213a2

IL13RA2 Alternative Names

IL13RA2, CD213A2, CT19, IL-13R, IL13BP [Homo sapiens]

Il13ra2, CD213a2 [Mus musculus]

IL13RA2 Background

Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Rα2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Rα2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Rα2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.

IL13RA2 Related Studies

1. Zhou G, et al.. (2005) Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells. J Virol. 79(9): 5272-7.
2. Osawa M, et al.. (2000) Characterization of the mouse interleukin-13 receptor alpha1 gene. Immunogenetics. 51(11): 974-81.
3. Nair BG, et al.. (2011) Nanotechnology platforms; an innovative approach to brain tumor therapy. Med Chem. 7(5): 488-503.
4. Benson M, et al.. (2006) A network-based analysis of the late-phase reaction of the skin. J Allergy Clin Immunol. 118(1): 220-5.