- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Interleukin 13 receptor, alpha 2 Protein Datasheet
IL13RA2 / IL13R Protein Price Inquiry ( Available Sizes )
- ≥1mg Bulk: Inquiring Price
IL13RA2 / IL13R Protein Product Information
A DNA sequence encoding the rat IL13RA2 (Q8VHK6) (Met1-Lys336) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
IL13RA2 / IL13R Protein QC Testing
|Purity:||> 90% as determined by SDS-PAGE||SDS-PAGE:
IL13RA2 / IL13R protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Leu 24|
The recombinant rat IL13RA2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 554 amino acids and has a predicted molecular mass of 63.4 kDa. The apparent molecular mass of the protein is approximately 89-93 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
IL13RA2 / IL13R Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
IL13RA2 / IL13R Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|IL-13RA2/CD213a2||Human||IL-13RA2/CD213a2/Fc Protein, Recombinant||10350-H03H|
|IL-13RA2/CD213a2||Mouse||IL-13RA2/CD213a2/Fc Protein, Recombinant||50061-M03H|
|IL-13RA2/CD213a2||Mouse||IL-13RA2/CD213a2 Protein, Recombinant||50061-M08H|
|IL-13RA2/CD213a2||Rat||IL-13RA2/IL13R Protein, Recombinant||80204-R02H|
|IL-13RA2/CD213a2||Rat||IL-13RA2/IL13R Protein, Recombinant||80204-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||IL13RA2/CD213a2 Antibody, Rabbit MAb||50061-R015|
|WB, ELISA||Rabbit Polyclonal Antibody||50061-RP01|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||50061-RP02|
IL13RA2 / IL13R Protein Description
Interleukin-13 receptor alpha2 chain(IL-13Rα2) is one of the receptor components for IL-13, a Th2 cell-derived pleiotropic immune regulatory cytokine. IL13Rα2 contains 3 fibronectin type-III domains, and binds as a monomer with high affinity to IL-13. IL-13Rα2 exists both on the cell membrane and in soluble form intracellularly which are generated from distinct transcripts. IL-13Rα2 was initially cloned from a kidney cell line and then found to be expressed in brain, spleen, liver, thymus, and also in the bone marrow, which are hemopoietic or hypervascular tissues. Soluble IL-13Rα2 was found in multiple mouse organs and was up-regulated in lungs following allergen challenge. IL-13Rα2 is expressed on certain types of cancer cells including glioblastoma, AIDS Kaposi's sarcoma, and head and neck cancer. In a IL13Rα2 transgenic mice model, the antitumor activity of IL13-PE, a receptor-directed cytotoxin was profoundly enhanced, providing elimination of established tumor in some xenografts. Comparisons of the human and murine receptors show that they are structurally conserved, share 59% aa identity.
- Kawakami K. 2005, Curr Gene Ther. 5 (2): 213-23.
- Tabata Y. et al., 2007, Curr Allergy Asthma Rep. 7 (5): 338-45.
- Yasuhiro T. et al., 2006, The Journal of Immunology. 177: 7905-12.
- Debra D Donaldson. et al., 1998, The Journal of Immunology. 161: 2317-24.
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