Anti-IL13RA2 Antibody

Cat: 80204-RP02

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All IL13RA2 Reagents

Anti-IL13RA2 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-IL13RA2 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Rat
Specificity
Rat IL13RA2
Immunogen
Recombinant Rat IL13RA2 / IL13R protein (Catalog#80204-R08H)
Preparation
Produced in rabbits immunized with purified, recombinant Rat IL13RA2 / IL13R (rR IL13RA2 / IL13R; Catalog#80204-R08H; Q8VHK6; Met1-Lys336). IL13RA2 / IL13R specific IgG was purified by Rat IL13RA2 / IL13R affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-IL13RA2 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL13RA2 Antibody (Rabbit Polyclonal antibody) Images

Rat IL13RA2 / CD213A2 Immunohistochemistry(IHC) 3114
Immunochemical staining of rat IL13RA2 in rat stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Rat IL13RA2 / CD213A2 Immunohistochemistry(IHC) 3115
Immunochemical staining of rat IL13RA2 in rat spleen with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Rat IL13RA2 / CD213A2 Immunohistochemistry(IHC) 3116
Immunochemical staining of rat IL13RA2 in rat liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Rat IL13RA2 / CD213A2 Immunohistochemistry(IHC) 3117
Immunochemical staining of rat IL13RA2 in rat brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

IL13RA2 Background Information

Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Rα2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Rα2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Rα2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.

Full Name
interleukin 13 receptor, alpha 2
References
  • Zhou G, et al.. (2005) Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells. J Virol. 79(9): 5272-7.
  • Osawa M, et al.. (2000) Characterization of the mouse interleukin-13 receptor alpha1 gene. Immunogenetics. 51(11): 974-81.
  • Nair BG, et al.. (2011) Nanotechnology platforms; an innovative approach to brain tumor therapy. Med Chem. 7(5): 488-503.
  • Benson M, et al.. (2006) A network-based analysis of the late-phase reaction of the skin. J Allergy Clin Immunol. 118(1): 220-5.
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