|Recombinant Human IL13 protein (Catalog#10369-H01H)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Human IL13 / ALRH (rh IL13 / ALRH; Catalog#10369-H01H; AAK53823.1; Gly 21-Asn 132). IL13 / ALRH specific IgG was purified by Human IL13 / ALRH affinity chromatography.|
This antibody can be used at 1:5000-1:10000 with the appropriate secondary reagents to detect Human IL13.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.