IL12RB1 Protein (CD212 Protein)

Interleukin 12 receptor, beta 1 (Cluster of Differentiation 212)

IL12RB1 Products

IL12RB1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL12RB1/CD212	Human	IL12RB1/CD212 Protein, Recombinant	11674-H08H

11674-H08H: Immobilized human IL12RB1 at 20 µg/ml (100 µl/well) can bind human IL12B with a linear ranger of 2.56-64 ng/ml. Measured by its binding ability in a functional ELISA.

IL12RB1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL12RB1/CD212	Human	Homo sapiens IL12RB1/CD212 cDNA Clone	HG11674-M

IL12RB1 Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-12 Family & Receptor>>IL12RB1/CD212

Immunology>>Cluster of Differentiation>>IL12RB1/CD212

IL12RB1 Alternative Names

IL12RB1, CD212, IL-12R-BETA1, IL12RB, MGC34454 [Homo sapiens]

Il12rb1, CD212, IL-12R[b] [Mus musculus]

IL12RB1 Background

Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of IL12RB1 and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. IL12RB1(CD212) Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. It associated with IL12RB2 it forms a functional, high affinity receptor for IL12. IL12RB1(CD212) associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

IL12RB1 Related Studies

Cleary AM, et al. (2003) Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. J Immunol. 170 (1): 597-603.
Suzuki Y, et al. (1997) Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 200 (1-2): 149-56.
Yamamoto K, et al. (1997) Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization. Cytogenet. Cell Genet. 77 (3-4): 257-8.

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