0 products, total $0.+86-400-890-9989      Login |  Register 中文한국어

Browse By Molecule:

Your Position: Home > IL12B / IL-12B Protein & Antibody (IL-12p40)

IL12B / IL-12B Protein & Antibody (IL-12p40)

Interleukin 12B

IL-12B Products

IL-12B Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IL-12B/IL-12p40 Human IL-12B/IL-12p40/Fc Protein, Recombinant 10052-H02H
IL-12B/IL-12p40 Human IL-12B/IL-12p40 Protein, Recombinant 10052-H08H
IL-12B/IL-12p40 Mouse IL12B / IL-12B Protein, Recombinant 51004-M02H
IL-12B/IL-12p40 Mouse IL12B / IL-12B Protein, Recombinant 51004-M08H
IL-12B/IL-12p40 Rat IL12B / IL-12B Protein, Recombinant 80352-R08H

  10052-H02H: Immobilized human IL12RB1 at 20 µg/ml (100 µl/well) can bind human IL12B with a linear ranger of 2.56-64 ng/ml. Measured by its binding ability in a functional ELISA.

  10052-H08H: Measured by its ability to bind biotinylated recombinant human IL12RB1 in a functional ELISA.

IL-12B Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
IL-12B/IL-12p40
ELISA Mouse Monoclonal Antibody 10052-MM01
Human
IL-12B/IL-12p40
WB, ELISA Rabbit Monoclonal Antibody 10052-R054
Human
IL-12B/IL-12p40
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10052-RP02
Human
IL-12B/IL-12p40
WB, ELISA Rabbit Polyclonal Antibody 10052-RP03

IL-12B ELISA Kit

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human IL-12B/IL-12p40 ELISA IL-12B/IL-12p40 ELISA Kit SEK10052
Human IL-12B/IL-12p40 ELISA IL-12B/IL-12p40 ELISA Kit SEKA10052

IL-12B cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IL-12B/IL-12p40 Human Homo sapiens IL-12B/IL-12p40 cDNA Clone(NM_002187.2)  HG10052-M
IL-12B/IL-12p40 Canine Canine IL12B cDNA Clone / ORF Clone DG70011-M
IL-12B/IL-12p40 Rat Rat IL12B cDNA Clone / ORF Clone RG80352-G

IL-12B Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-12B/IL-12p40

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-12B/IL-12p40

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-12 Family & Receptor>>IL-12B/IL-12p40

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>IL-12B/IL-12p40

IL-12B Alternative Names

IL-12B, IL12B, CLMF, CLMF2, NKSF, NKSF2 [Homo sapiens]

Il-12b, p40, Il12b, Il-12p40, Il12p40, RP23-388G23.1 [Mus musculus]

IL-12B Background

Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.

IL-12B Related Studies

  1. Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
  2. Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
  3. Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
_×