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IL12B/IL-12B Protein, Antibody, ELISA Kit, cDNA Clone

Mouse IL12B/IL-12B Protein

Expression host: Human Cells
  • Slide 1
51004-M08H-20
51004-M08H-50
20 µg / $160
50 µg / $320
Add to Cart
Expression host: Human Cells
  • Slide 1
51004-MCCH-20
51004-MCCH-50
20 µg / $160
50 µg / $320
Add to Cart
Expression host: Human Cells
  • Slide 1
51004-M02H-20
51004-M02H-50
20 µg / $190
50 µg / $380
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Rat IL12B/IL-12B Protein

Expression host: Human Cells
  • Slide 1
80352-R08H-10
80352-R08H-20
10 µg / $150
20 µg / $250
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Expression host: Human Cells
  • Slide 1
80352-R02H-10
80352-R02H-20
10 µg / $150
20 µg / $260
Add to Cart

Marmoset IL12B/IL-12B Protein

Expression host: Human Cells
  • Slide 1
90289-C02H-10
90289-C02H-20
10 µg / $110
20 µg / $190
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Human IL12B/IL-12B Protein

Description: Active
Expression host: Human Cells
  • Slide 1
10052-H02H-5
10052-H02H-10
10052-H02H-20
5 µg / $38
10 µg / $110
20 µg / $210
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
10052-H08H-10
10052-H08H-20
10 µg / $140
20 µg / $250
Add to Cart

IL12B/IL-12B Related Areas

IL12B/IL-12B Related Pathways

IL12B/IL-12B Related Product

IL12B/IL-12B Summary & Protein Information

IL12B/IL-12B Related Information

IL12B/IL-12B Background

Gene Summary: IL12B gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by IL12B gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL12B gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL12B gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subunit structure: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide- linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
Subcellular location: Secreted.
Post-translational: Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
Involvement in disease: Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]: This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non- tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Note=The disease is caused by mutations affecting the gene represented in this entry.
Psoriasis 11 (PSORS11) [MIM:612599]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily.
Contains 1 fibronectin type-III domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
General information above from UniProt

Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.

IL12B/IL-12B Alternative Name

CLMF,CLMF2,IL12B,IL-12B,NKSF,NKSF2, [human]
Il12b,Il-12b,Il12p40,Il-12p40,RP23-388G23.1,P40, [mouse]

IL12B/IL-12B Related Studies

  • Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
  • Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
  • Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.
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