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> IL12B / IL-12B Protein & Antibody (IL-12p40) IL12B / IL-12B Protein & Antibody (IL-12p40)
Interleukin 12B
IL-12B Products
IL-12B Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-12B/IL-12p40 | Human | IL-12B/IL-12p40/Fc Protein, Recombinant |
10052-H02H |
| IL-12B/IL-12p40 | Human | IL-12B/IL-12p40 Protein, Recombinant |
10052-H08H |
| IL-12B/IL-12p40 | Mouse | IL12B / IL-12B Protein, Recombinant | 51004-M02H |
| IL-12B/IL-12p40 | Mouse | IL12B / IL-12B Protein, Recombinant | 51004-M08H |
| IL-12B/IL-12p40 | Rat | IL12B / IL-12B Protein, Recombinant | 80352-R08H |
IL-12B Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human IL-12B/IL-12p40 |
ELISA | Mouse Monoclonal Antibody | 10052-MM01 |
| Human IL-12B/IL-12p40 |
WB, ELISA | Rabbit Monoclonal Antibody | 10052-R054 |
| Human IL-12B/IL-12p40 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10052-RP02 |
| Human IL-12B/IL-12p40 |
WB, ELISA | Rabbit Polyclonal Antibody | 10052-RP03 |
IL-12B ELISA Kit
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human IL-12B/IL-12p40 | ELISA | IL-12B/IL-12p40 ELISA Kit | SEK10052 |
| Human IL-12B/IL-12p40 | ELISA | IL-12B/IL-12p40 ELISA Kit | SEKA10052 |
IL-12B cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-12B/IL-12p40 | Human | Homo sapiens IL-12B/IL-12p40 cDNA Clone(NM_002187.2) | HG10052-M |
| IL-12B/IL-12p40 | Canine | Canine IL12B cDNA Clone / ORF Clone | DG70011-M |
| IL-12B/IL-12p40 | Rat | Rat IL12B cDNA Clone / ORF Clone | RG80352-G |
IL-12B Related Areas
Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-12B/IL-12p40
Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-12B/IL-12p40
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-12 Family & Receptor>>IL-12B/IL-12p40
Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>IL-12B/IL-12p40
IL-12B Alternative Names
IL-12B, IL12B, CLMF, CLMF2, NKSF, NKSF2 [Homo sapiens]
Il-12b, p40, Il12b, Il-12p40, Il12p40, RP23-388G23.1 [Mus musculus]
IL-12B Background
Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.
IL-12B Related Studies
- Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
- Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
- Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.
