>Human Cell Expressed
>Mouse IL12B / IL-12B Protein (His Tag)
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Interleukin 12b Protein Datasheet
IL12B / IL-12B Protein Price Inquiry ( Available Sizes )
IL12B / IL-12B Protein Product Information
A DNA sequence encoding the mouse IL12B (Met1-Ser335) was expressed with a C-terminal polyhistidine tag.
|Expression Host:||Human Cells|
IL12B / IL-12B Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
IL12B / IL-12B protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met 23|
The recombinant mouse IL12B comprises 324 amino acids and has a predicted molecular mass of 37.2 kDa. The apparent molecular mass of the protein is approximately 47-51 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
IL12B / IL-12B Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
IL12B / IL-12B Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|IL-12B/IL-12p40||Human||IL-12B/IL-12p40/Fc Protein, Recombinant||10052-H02H|
|IL-12B/IL-12p40||Human||IL-12B/IL-12p40 Protein, Recombinant||10052-H08H|
|IL-12B/IL-12p40||Mouse||IL12B / IL-12B Protein, Recombinant||51004-M02H|
|IL-12B/IL-12p40||Mouse||IL12B / IL-12B Protein, Recombinant||51004-M08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|ELISA||Mouse Monoclonal Antibody||10052-MM01|
|WB, ELISA||Rabbit Monoclonal Antibody||10052-R054|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||10052-RP02|
|WB, ELISA||Rabbit Polyclonal Antibody||10052-RP03|
IL12B / IL-12B Protein Description
Interleukin 12 (IL-12), also known as NKSF or CLMF, is a disulfide-linked heterodimeric cytokine composed of a 35kDa subunit P35 and a 40kDa subunit P40, also designated as IL-12A and IL-12B. IL-12 is predominantly produced by macrophages and B lymphocytes and plays an important role in the activities of natural killer cells and T lymphocytes. It is involved in the differentiation and development of Th1 cells, enhancement of natural killer cells’ cytolytic function and mitogenic effects, as well as induction of IFN-gamma during which it can synergize with other IFN-gamma inducers. A large excess of monomeric IL-12B is also secreted by the cells producing IL-12, and exhibits no demonstrable biological activity. Overexpression of IL-12B has been shown to be associated with the pathogenesis of multiple sclerosis.
- Ling, P. et al., 1995, J. Immunol. 154: 116-27.
- Thierfelder, WE. et al., 1996, Nature. 382: 171-4.
- Kato, K. et al., 1996, Proc. Natl. Acad. Sci. 93: 9085-89.
- Kim, JH. et al., 1997, Clin. Exp. Immunol. 108: 243-50.