Anti-IL12B Antibody


Application | Dilution | Notes |
---|---|---|
ELISA | 1:1000-1:2000 |
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.
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Product Description | Host | Clonality | Application | Catalog# (PDF) |
---|---|---|---|---|
Anti-IL12B Antibody | Mouse | Monoclonal | ELISA | 80352-MM01 |
Anti-IL12B Antibody | Rabbit | Polyclonal | ELISA | 80352-T16 |
Anti-IL12B Antibody | Rabbit | Polyclonal | ELISA,IHC-P | 80352-T24 |
Anti-IL12B Antibody | Rabbit | Monoclonal | ELISA | 80352-R106 |
Anti-IL12B Antibody | Rabbit | Polyclonal | ELISA | 80352-RP01 |
Anti-IL12B Antibody | Rabbit | Monoclonal | ELISA | 80352-R010 |
Anti-IL12B Antibody | Rabbit | Polyclonal | ELISA | 51004-RP01 |
Anti-IL12B Antibody | Rabbit | Polyclonal | ELISA | 51004-T16 |
Anti-IL12B Antibody | Rabbit | Monoclonal | ELISA | 51004-R020 |
Anti-IL12B Antibody | Mouse | Monoclonal | ELISA(Cap) | 10052-MM05 |
Anti-IL12B Antibody | Rabbit | Monoclonal | ELISA,ELISA(Det) | 10052-R054 |
Anti-IL12B Antibody | Rabbit | Polyclonal | ELISA | 10052-RP02 |
Anti-IL12B Antibody | Rabbit | Polyclonal | ELISA | 10052-RP03 |
Anti-IL12B Antibody | Rabbit | Polyclonal | ELISA | 10052-T16 |
Anti-IL12B Antibody | Mouse | Monoclonal | ELISA | 10052-MM11 |