Anti-IL12B Antibody

Cat: 10052-R054
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Anti-IL12B Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-IL12B Antibody
Validated applications
ELISA,ELISA(Det)
Species reactivity
Reacts with: Human
Specificity
Human IL12B
Immunogen
Recombinant Human IL12B protein (Catalog#10052-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL12B / p40 (rh IL12B; Catalog#10052-H08H; Met 1-Ser 328; NP_002178.2) .
Source
Monoclonal Rabbit IgG Clone #54
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL12B Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
ELISA(Det) 1:1000-1:10000 This antibody will detect Human IL12B / IL-12B in ELISA pair set (Catalog: # SEKB10052). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10052-MM05).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL12B Antibody Alternative Names
Anti-CLMF Antibody;Anti-CLMF2 Antibody;Anti-IL-12B Antibody;Anti-IL12 p40 Antibody;Anti-IMD28 Antibody;Anti-IMD29 Antibody;Anti-NKSF Antibody;Anti-NKSF2 Antibody
IL12B Background Information

Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 12B
References
  • Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
  • Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
  • Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL12B Antibody Mouse Monoclonal ELISA 80352-MM01
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 80352-T16
    Anti-IL12B Antibody Rabbit Polyclonal ELISA,IHC-P 80352-T24
    Anti-IL12B Antibody Rabbit Monoclonal ELISA 80352-R106
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 80352-RP01
    Anti-IL12B Antibody Rabbit Monoclonal ELISA 80352-R010
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 51004-RP01
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 51004-T16
    Anti-IL12B Antibody Rabbit Monoclonal ELISA 51004-R020
    Anti-IL12B Antibody Mouse Monoclonal ELISA 10052-MM01
    Anti-IL12B Antibody Mouse Monoclonal ELISA(Cap) 10052-MM05
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 10052-RP02
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 10052-RP03
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 10052-T16
    Anti-IL12B Antibody Mouse Monoclonal ELISA 10052-MM11
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