Anti-IL12B Antibody

Cat: 10052-RP03
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All IL12B Reagents
Anti-IL12B Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL12B Antibody
Validated applications
Species reactivity
Reacts with: Human
Human IL12B
Recombinant Human IL12B protein (Catalog#10052-H08H)
Produced in rabbits immunized with purified, recombinant Human IL12B (rhIL12B; Catalog#10052-H08H; Met 1-Ser 328; NP_002178.2). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL12B Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL12B Antibody Alternative Names
Anti-CLMF Antibody;Anti-CLMF2 Antibody;Anti-IL-12B Antibody;Anti-IL12 p40 Antibody;Anti-IMD28 Antibody;Anti-IMD29 Antibody;Anti-NKSF Antibody;Anti-NKSF2 Antibody
IL12B Background Information

Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 12B
  • Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
  • Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
  • Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL12B Antibody Mouse Monoclonal ELISA 80352-MM01
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 80352-T16
    Anti-IL12B Antibody Rabbit Polyclonal ELISA,IHC-P 80352-T24
    Anti-IL12B Antibody Rabbit Monoclonal ELISA 80352-R106
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 80352-RP01
    Anti-IL12B Antibody Rabbit Monoclonal ELISA 80352-R010
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 51004-RP01
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 51004-T16
    Anti-IL12B Antibody Rabbit Monoclonal ELISA 51004-R020
    Anti-IL12B Antibody Mouse Monoclonal ELISA 10052-MM01
    Anti-IL12B Antibody Mouse Monoclonal ELISA(Cap) 10052-MM05
    Anti-IL12B Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10052-R054
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 10052-RP02
    Anti-IL12B Antibody Rabbit Polyclonal ELISA 10052-T16
    Anti-IL12B Antibody Mouse Monoclonal ELISA 10052-MM11
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