IL11RA / IL-11RA Protein & Antibody

IL11RA / IL-11RA Protein

IL11RA / IL-11RA Products

IL11RA / IL-11RA Protein, Recombinant

Molecule	Species	Description	Cat. No
IL11RA/IL-11RA	Human	IL11RA/IL-11RA Protein, Recombinant	10252-H08H
IL11RA/IL-11RA	Mouse	IL11RA/IL-11RA Protein, Recombinant	50075-M08H

  10252-H08H:  Measured by its ability to bind human IL6ST in a functional Elisa.

  50075-M08H:  Measured by its ability to bind mouse IL6ST in a functional Elisa.

IL11RA / IL-11RA Antibody

Molecule	Application	Description	Cat. No
Mouse IL11RA/IL-11RA	WB, ELISA	IL11RA/IL-11RA Antibody, Rabbit MAb	50075-R025

IL11RA / IL-11RA cDNA Clone

Molecule	Species	Description	Cat. No
IL11RA/IL-11RA	Human	Homo sapiens IL11RA/IL-11RA transcript variant 1 cDNA Clone(NM_004512.3)	HG10252-M
IL11RA/IL-11RA	Mouse	Mus musculus IL11RA1 cDNA Clone	MG50075-M
IL11RA/IL-11RA	Rat	Rat IL11RA/IL-11RA transcript variant 1 cDNA Clone	RG80179-G
IL11RA/IL-11RA	Cynomolgus	Cynomolgus monkey IL18RAP cDNA Clone / ORF Clone	KG90126-G

IL11RA / IL-11RA Alternative Names

IL11RA, hCG_2011440, MGC2146 [Homo sapiens]

Il11ra1, Il11ra, Il-11ra, Il11ra2, RP23-167I12.2, AI314697, GP130, NR1 [Mus musculus]

IL11RA / IL-11RA Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-6 Family & Receptor>>IL11RA/IL-11RA

IL11RA / IL-11RA Background

Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.

IL11RA / IL-11RA Related Studies

1. Van Leuven F, et al. (1996) Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. Genomics. 31 (1): 65-70.
2. Yoshizaki A, et al. (2006) Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. Int J Oncol. 29 (4): 869-76.
3. Karube K, et al. (2006) Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha. Ann Oncol. 17 (1): 110-6.