IL10RB Protein & Antibody (CDw210b)

Interleukin 10 Receptor, beta (Cluster of Differentiation w210b)

IL10RB Products

IL10RB Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-10RB	Human	IL-10RB/Fc Protein, Recombinant	10945-H03H
IL-10RB	Human	IL-10RB Protein, Recombinant	10945-H08H
IL-10RB	Mouse	IL-10RB Protein, Recombinant	50846-M02H
IL-10RB	Mouse	IL-10RB Protein, Recombinant	50846-M08H

  10945-H03H: Immobilized human IL28B at 20 μg/ml (100 μl/well) can bind human IL10RB-Fc with a linear ranger of  3.125 - 25 μg/ml. Measured by its binding ability in a functional ELISA.

  10945-H08H  Measured by its ability to compete with human IL10RB-Fc for binding to immobilized human IL28B in a functional ELISA assay.

IL10RB Antibody

Molecule	Application	Description	Cat. No
Human IL10RB	WB, ELISA	Mouse Monoclonal Antibody	10945-MM02
Human IL10RB	WB, ELISA	Rabbit Polyclonal Antibody	10945-RP01
Human IL10RB	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10945-RP02

IL10RB ELISA Kit

Molecule	Application	Description	Cat. No
Human IL10RB	ELISA	IL10RB ELISA Kit	SEK10945

IL10RB cDNA Clone

Molecule	Species	Description	Cat. No
IL-10RB	Human	Homo sapiens IL-10RB/CDw210b cDNA Clone(NM_000628.3)	HG10945-M
IL-10RB	Mouse	Mouse IL10Rb cDNA Clone / ORF Clone	MG50846-G
IL-10RB	Rat	Rat IL10RB cDNA Clone / ORF Clone	RG80184-G
IL-10RB	Cynomolgus	Cynomolgus monkey IL10RB cDNA Clone / ORF Clone	KG90116-G

IL10RB Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-10RB/CDw210b

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>> IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>> IL-10RB/CDw210b

IL10RB Alternative Names

IL10RB, CDw210b, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2 [Homo sapiens]

Il10rb, 6620401D04Rik, AI528744, CRF2-4, Crfb4, D16H21S58, D21S58h, IL-10R2, Il10r2 [Mus musculus]

IL10RB Background

Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

IL10RB Related Studies

1. Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46.
2. Gong QM, et al. (2009) Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection. J Viral Hepat. 16(9): 674-80.
3. Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.