|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Interleukin 10 receptor, beta Protein Datasheet
IL10RB / IL-10R2 Protein Price Inquiry ( Available Sizes )
- ≥1mg Bulk: Inquiring Price
IL10RB / IL-10R2 Protein Product Information
A DNA sequence encoding the rat IL10RB (Met1-Pro222) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
IL10RB / IL-10R2 Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
IL10RB / IL-10R2 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met 22|
The recombinant rat IL10RB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 442 amino acids and has a predicted molecular mass of 50.7 kDa. The apparent molecular mass of the protein is approximately 68 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
IL10RB / IL-10R2 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
IL10RB / IL-10R2 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|IL-10RB||Human||IL-10RB/Fc Protein, Recombinant||10945-H03H|
|IL-10RB||Human||IL-10RB Protein, Recombinant||10945-H08H|
|IL-10RB||Mouse||IL-10RB Protein, Recombinant||50846-M02H|
|IL-10RB||Mouse||IL-10RB Protein, Recombinant||50846-M08H|
|IL-10RB||Rat||IL10RB / IL10R2 Protein, Recombinant||80184-R02H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||Mouse Monoclonal Antibody||10945-MM02|
|WB, ELISA||Rabbit Polyclonal Antibody||10945-RP01|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||10945-RP02|
|WB, ELISA||IL10RB / IL10R2 Antibody (Antigen Affinity Purified)||50846-RP02|
IL10RB / IL-10R2 Protein Description
The functional IL-10 receptor consists of two polypeptide chains, a ligand binding chain IL-10 Rα (IL-10 R1) and a signal transduction molecule known as IL-10 Rβ (IL-10 R2). Both chains of the IL-10 R are expressed on many hematopoietic cells, including lymphocytes, monocytes and neutrophils, with the IL-10 Rβ chain expressed at higher levels than the IL-10 Rα chain in most cases. Interleukin 10 receptor beta (IL-10 Rβ) , also known as CD210b and CRF2-4, is an 80-85 kDa member of the type I I cytokine receptor family of proteins and contains two fibronectin type-III domains. The widely expressed IL-10 Rβ serves as a signal transducing accessory chain not only for IL-10, but also for other interleukins including IL-22, -28A, -28B and -29 (plus IL-26 in human) when complexed to the ligand-binding chains. It has been shown that the action of IL-10 delivered through its receptor can affect a variety of immune functions including inhibition of pro-inflammatory cytokine synthesis and regulation of the growth and function of B cells and antigen presenting cells. The human IL-10 Rβ shares 69% homology to its mouse counterpart in amino acid sequence. Research evidences indicated that defects in IL10RB are associated with susceptibility to hepatitis B virus infection.
- Liu Y. et al., 1994, J Immunol. 152:1821-9.
- Kotenko SV. et al.,1997, EMBO J. 16 (19): 5894-903.
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- Kotenko SV. et al., 2001, J Biol Chem. 276: 2725-32.
- Crepaldi L. et al., 2001, J Immunol. 167: 2312-22.
- Dinant S. J. et al., 2007, Surg Res. 141 (2): 176-82.