Anti-IL-9 Antibody

Cat: 11844-RP02
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All IL-9 Reagents
CRO Services

All IL-9 Reagents
Anti-IL-9 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL-9 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL-9
Immunogen
Recombinant Human IL-9 protein (Catalog#11844-H08B)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL-9 (rh IL-9; Catalog#11844-H08B; NP_000581.1; Gln 19-Il4144). IL-9 specific IgG was purified by Human IL-9 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-9 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.1-0.2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-9 Antibody Alternative Names
Anti-HP40 Antibody;Anti-IL-9 Antibody;Anti-P40 Antibody
IL-9 Background Information

Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. IL-9 is a key molecule that affects differentiation of TH17 cells and Treg function. IL-9 predominantly produced by TH17 cells, synergizes with TGF-β1 to differentiate naïve CD4+ T cells into TH17 cells, while IL-9 secretion by TH17 cells is regulated by IL-23. Interestingly, IL-9 enhances the suppressive functions of FoxP3+ CD4+ Treg cells in vitro, and absence of IL-9 signaling weakens the suppressive activity of nTregs in vivo, leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. The mechanism of IL-9 effects on TH17 and Tregs is through activation of STAT3 and STAT5 signaling. Our findings highlight a role of IL-9 as a regulator of pathogenic versus protective mechanisms of immune responses.

Full Name
interleukin 9
References
  • Elyaman W, et al. (2009) IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 106(31): 12885-90.
  • Dong Q, et al. (1999) IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur J Immunol. 29(7): 2130-9.
  • Kimura Y, et al. (1995) Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. Int Immunol. 7(1): 115-20.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-9 Antibody Rabbit Polyclonal ELISA 80459-RP01
    Anti-IL-9 Antibody Rabbit Monoclonal ELISA 80459-R030
    Anti-IL-9 Antibody Mouse Monoclonal ELISA 80459-MM03
    Anti-IL-9 Antibody Rabbit Polyclonal ELISA 80459-T16
    Anti-IL-9 Antibody Rabbit Polyclonal WB,IHC-P 100318-T40
    Anti-IL-9 Antibody Rabbit Monoclonal ELISA 11844-R103
    Anti-IL-9 Antibody Rabbit Polyclonal ELISA 11844-RP01
    Anti-IL-9 Antibody Rabbit Polyclonal ELISA 11844-T16
    info info
    添加购物车成功! 添加购物车失败!