0 products, total $0.+86-400-890-9989      Login |  Register 中文한국어

Browse By Molecule:

Your Position: Home > IL-8 Protein (CXCL8 Protein)

IL-8 Protein (CXCL8 Protein)

Interleukin-8 (C-X-C motif Ligand 8)

IL-8 Products

IL-8 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IL-8/CXCL8 Human IL-8/CXCL8/Fc Protein, Recombinant 10098-H01H1
IL-8/CXCL8 Human IL-8/CXCL8/Fc Protein, Recombinant 10098-H01H2
IL-8/CXCL8 Human IL-8/CXCL8 Protein, Recombinant 10098-HNCH1
IL-8/CXCL8 Human IL-8/CXCL8(aa 6-77) Protein, Recombinant 10098-HNCH2
IL-8/CXCL8 Canine IL-8 / CXCL8 Protein, with Native 70009-DNAE

IL-8 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IL-8/CXCL8 Human Homo sapiens IL-8/CXCL8 cDNA Clone(NM_000584.2)  HG10098-M
IL-8/CXCL8 Cynomolgus Cynomolgus monkey IL8 Gene cDNA Clone / ORF Clone CG90280-G

IL-8 Alternative Names

IL8, CXCL8, LYNAP, NAF, GCP1, GCP-1, LECT, LUCT, MDNCF, MONAP, NAP-1, NAP1

IL-8 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-8/CXCL8

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other Interleukin & Receptor>>IL-8/CXCL8

IL-8 Background

Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.

IL-8 Related Studies

  1. Mukaida N. (2003) Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 284(4): L566-77.
  2. Brat DJ, et al. (2005) The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 7(2): 122-33.
  3. Bendrik C, et al. (2009) Estradiol increases IL-8 secretion of normal human breast tissue and breast cancer in vivo. J Immunol. 182(1): 371-8.

 

IL-8 related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
_×