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IL-8/CXCL8 Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active
Expression host: Human Cells
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10098-H01H1-50
10098-H01H1-100
50 µg / $198
100 µg / $348
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Expression host: Human Cells
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10098-HNCH1-50
10098-HNCH1-100
50 µg / $198
100 µg / $348
Add to Cart
Description: Active
Expression host: Human Cells
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10098-H01H2-50
10098-H01H2-100
50 µg / $198
100 µg / $348
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Expression host: Human Cells
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10098-HNCH2-50
10098-HNCH2-100
50 µg / $198
100 µg / $348
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Expression host: E. coli
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10098-HNAE-50
10098-HNAE-20
50 µg / $198
20 µg / $108
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Expression host: E. coli
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70009-DNAE-20
70009-DNAE-50
20 µg / $158
50 µg / $298
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Description: Active
Expression host: E. coli
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90280-CNAE-20
90280-CNAE-50
20 µg / $158
50 µg / $298
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IL-8/CXCL8 Related Areas

IL-8/CXCL8 Related Pathways

IL-8/CXCL8 Related Product

    IL-8/CXCL8 Summary & Protein Information

    IL-8/CXCL8 Related Information

    IL-8/CXCL8 Background

    Gene Summary: The IL-8 protein encoded by this IL8 gene is a member of the CXC chemokine family. This IL-8 chemokine is one of the major mediators of the inflammatory response. This IL-8 chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This IL8 gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This IL8 gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
    General information above from NCBI
    Subunit structure: Homodimer.
    Subcellular location: Secreted.
    Induction: By ER stress in a DDIT3/CHOP-dependent manner.
    Post-translational: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.
    Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
    Sequence similarity: Belongs to the intercrine alpha (chemokine CxC) family.
    General information above from UniProt

    Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.

    IL-8/CXCL8 Alternative Name

    IL-8/CXCL8 Related Studies

  • Mukaida N. (2003) Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 284(4): L566-77.
  • Brat DJ, et al. (2005) The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 7(2): 122-33.
  • Bendrik C, et al. (2009) Estradiol increases IL-8 secretion of normal human breast tissue and breast cancer in vivo. J Immunol. 182(1): 371-8.
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