IL-6R Protein & Antibody (CD126)

Interleukin 6 Receptor (Cluster of Differentiation 126)

IL-6R Alternative Names

IL-6R, CD126, IL6R, IL-6R-1, IL-6R-alpha, IL6RA, MGC104991

IL-6R Protein & Antibody & cDNA Clone Products

Sino Biological offers a comprehensive set of research tools (proteins, antibodies and cDNA clones) for interleukin-6 family related research. We offer recombinant proteins of IL-6 family ligands and receptors from human and mouse. Our antibody products include mouse monoclonal and rabbit polyclonal antibodies for application such as ELISA, Western Blotting, IHC, etc. All of our antibodies were generated with recombinant full length protein as immunogen, which ensures better binding affinity and specificity to the native protein.

IL-6R Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-6R/CD126	Human	IL-6R/CD126 Protein, Recombinant	10398-H08H
IL-6R/CD126	Mouse	IL-6R/CD126 Protein, Recombinant	50280-M08H

  10398-H08H: Immobilized recombinant human IL-6 at 8 μg/mL (100μl/well) can bind recombinant human IL6R with a linear range of 1.25 - 20.0 ng/ml. Measured by its binding ability in a functional ELISA.

IL-6R Antibody

Molecule	Application	Description	Cat. No
Human IL-6R/CD126	ELISA	Mouse Monoclonal Antibody	10398-MM01
Human IL-6R/CD126	ELISA	Rabbit Polyclonal Antibody	10398-RP02
Human IL-6R/CD126	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10398-RP03
Mouse IL-6R/CD126	WB, ELISA	IL-6R/CD126 Antibody, Rabbit MAb	50280-R005
Mouse IL-6R/CD126	WB, ELISA	Rabbit Polyclonal Antibody	50280-RP01
Mouse IL-6R/CD126	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50280-RP02

CD126/IL-6R ELISA Kit

Molecule	Application	Description	Cat. No
Human CD126/IL-6R	ELISA	CD126/IL-6R ELISA Kit	SEK10398

IL-6R cDNA Clone

Molecule	Species	Description	Cat. No
CD126/IL-6R	Human	Homo sapiens IL-6R/CD126 transcript variant 1 cDNA Clone(NM_000565.2)	HG10398-M

IL-6R Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-6R/CD126

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-6 Family & Receptor>>IL-6R/CD126

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL-6R/CD126

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL-6R/CD126

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Other>>IL-6R/CD126

IL-6R Background

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

IL-6R Related Studies

1. Barillé S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
2. Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.