All IL-6R reagents are produced in house and quality controlled, including 14 IL-6R Antibody, 3 IL-6R ELISA, 41 IL-6R Gene, 6 IL-6R Lysate, 6 IL-6R Protein, 2 IL-6R qPCR. All IL-6R reagents are ready to use.
Recombinant IL-6R proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
IL-6Rantibodies are validated with different applications, which are FCM, ELISA, ELISA(Cap), ICC/IF, IF, WB, Neutralization.
IL-6RcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL-6R of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL-6RELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.