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IL-6R / CD126 Neutralizing Antibody

  • IL-6R / CD126 Neutralizing Antibody
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Human IL6R Antibody Product Information
Immunogen:Recombinant Human IL-6R / CD126 protein (Catalog#10398-H08H)
Clone ID:3H7D3H1
Ig Type:Mouse IgG1
Concentration:
Endotoxin:Please contact us for more information.
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126; Catalog#10398-H08H; NP_000556.1; Met1-Pro365). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human IL6R Antibody Neutralization Application Image
IL-6R / CD126 Neutralizing Antibody
[Click to enlarge image]
Caption:
IL-6 Rα Enhancement of IL6-dependent Inhibition of Cell Proliferation was Neutralized by Human IL-6 Rα Neutralizing Antibody in the M1 mouse myeloid leukemia cell line. Enhancement of Recombinant Human IL6 (100 ng/mL) activity elicited by Recombinant Human IL-6 Rα (50 ng/mL) is neutralized by increasing concentrations of Human IL6 Rα neutralizing Monoclonal Antibody (Catalog 10398-MM08H). The IC50 is typically 0.15-0.6 µg/mL.
Other IL6R Antibody Products
Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
IL6R/IL-6R/CD126 Background

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human IL6R/IL-6R/CD126 References
  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
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    Catalog: 10398-MM08-500
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"